Zetia
E468959
Zetia is a prescription cholesterol-lowering medication (generic name ezetimibe) that reduces intestinal absorption of cholesterol and is marketed by Merck & Co.
Statements (39)
| Predicate | Object |
|---|---|
| instanceOf |
cholesterol-lowering medication
ⓘ
lipid-lowering agent ⓘ pharmaceutical drug ⓘ |
| actsOn | small intestine ⓘ |
| canBeCombinedWith |
atorvastatin
ⓘ
simvastatin ⓘ statins ⓘ |
| hasActiveIngredient | ezetimibe ⓘ |
| hasATCCode | C10AX09 ⓘ |
| hasCommonSideEffect |
abdominal pain
ⓘ
diarrhea ⓘ fatigue ⓘ headache ⓘ |
| hasDosageForm | tablet ⓘ |
| hasDrugClass | cholesterol absorption inhibitor ⓘ |
| hasGenericName | ezetimibe NERFINISHED ⓘ |
| hasIndication |
patients not adequately controlled with statins alone
ⓘ
patients with primary hyperlipidemia ⓘ |
| hasPregnancyCategory | C (US, historical) ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasSeriousSideEffect |
elevated liver enzymes
ⓘ
myopathy ⓘ rhabdomyolysis ⓘ |
| hasTypicalDose | 10 mg once daily ⓘ |
| isContraindicatedIn |
patients with active liver disease
ⓘ
patients with unexplained persistent elevations in hepatic transaminases ⓘ |
| isMarketedBy |
MSD
NERFINISHED
ⓘ
Merck & Co. NERFINISHED ⓘ |
| isUsedWith | dietary therapy ⓘ |
| mayIncrease | HDL cholesterol levels ⓘ |
| mayReduce | triglyceride levels ⓘ |
| reduces |
LDL cholesterol levels
ⓘ
intestinal absorption of cholesterol ⓘ total cholesterol levels ⓘ |
| targets | NPC1L1 transporter NERFINISHED ⓘ |
| treats |
homozygous familial hypercholesterolemia
ⓘ
homozygous sitosterolemia ⓘ hypercholesterolemia ⓘ primary hyperlipidemia ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.