H2 receptor antagonist cimetidine
E436638
H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.
All labels observed (2)
| Label | Occurrences |
|---|---|
| H2 receptor antagonist cimetidine canonical | 1 |
| Tagamet | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4394578 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: H2 receptor antagonist cimetidine Context triple: [James Black, developed, H2 receptor antagonist cimetidine]
-
A.
Pepcid
Pepcid is a widely used over-the-counter and prescription heartburn and acid reflux medication whose brand is owned by Kenvue.
-
B.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
-
C.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
D.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
E.
Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: H2 receptor antagonist cimetidine Target entity description: H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.
-
A.
Pepcid
Pepcid is a widely used over-the-counter and prescription heartburn and acid reflux medication whose brand is owned by Kenvue.
-
B.
Toclafane
The Toclafane are a race of deadly, cybernetic spheres revealed to be the future remnants of humanity in the Doctor Who universe, serving as instruments of mass destruction under the Master.
-
C.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
D.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
E.
Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
- F. None of above. chosen
Statements (53)
| Predicate | Object |
|---|---|
| instanceOf |
H2 receptor antagonist
ⓘ
anti-ulcer medication ⓘ histamine H2 receptor blocker ⓘ pharmaceutical drug ⓘ |
| actsOn |
gastric parietal cell
ⓘ
histamine H2 receptor NERFINISHED ⓘ |
| belongsToGeneration | first-generation H2 blocker ⓘ |
| developedBy | Smith, Kline & French NERFINISHED ⓘ |
| eliminatedPrimarilyBy | kidney ⓘ |
| hasAdverseEffect |
confusion in elderly patients
ⓘ
diarrhea ⓘ elevated serum prolactin ⓘ gynecomastia ⓘ headache ⓘ impotence in males ⓘ rash ⓘ |
| hasATCCode | A02BA01 ⓘ |
| hasBioavailability | about 60–70 percent ⓘ |
| hasCASNumber | 51481-61-9 ⓘ |
| hasDrugClass |
H2 receptor antagonist
ⓘ
anti-secretory agent ⓘ gastric acid secretion inhibitor ⓘ |
| hasDrugInteractionEffect |
increases plasma concentration of diazepam
ⓘ
increases plasma concentration of phenytoin ⓘ increases plasma concentration of theophylline ⓘ increases plasma concentration of warfarin ⓘ |
| hasEliminationHalfLife | about 2 hours in adults with normal renal function ⓘ |
| hasIUPACName | N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine ⓘ |
| hasMechanismOfAction |
competitive antagonist at histamine H2 receptors
ⓘ
reduces gastric acid secretion by blocking H2 receptors on parietal cells ⓘ |
| hasMolecularFormula | C10H16N6S ⓘ |
| hasRouteOfAdministration |
intramuscular
ⓘ
intravenous ⓘ oral ⓘ |
| hasTradeName | Tagamet NERFINISHED ⓘ |
| indicatedFor |
Zollinger–Ellison syndrome
NERFINISHED
ⓘ
duodenal ulcer ⓘ gastric ulcer ⓘ gastroesophageal reflux disease ⓘ prevention of stress-related mucosal damage ⓘ |
| inhibits |
CYP1A2
NERFINISHED
ⓘ
CYP2C9 NERFINISHED ⓘ CYP2D6 NERFINISHED ⓘ CYP3A4 NERFINISHED ⓘ cytochrome P450 enzymes ⓘ |
| reduces |
acetylcholine-stimulated gastric acid secretion
ⓘ
basal gastric acid secretion ⓘ food-stimulated gastric acid secretion ⓘ gastrin-stimulated gastric acid secretion ⓘ histamine-stimulated gastric acid secretion ⓘ nocturnal gastric acid secretion ⓘ |
| wasFirstApprovedIn | 1977 in the United States ⓘ |
| wasFirstInClass | first marketed H2 receptor antagonist ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: H2 receptor antagonist cimetidine Description of subject: H2 receptor antagonist cimetidine is a pioneering anti-ulcer medication that reduces stomach acid production by blocking histamine H2 receptors in the gastric parietal cells.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Tagamet