Graves disease
E417002
Graves disease is an autoimmune disorder that causes hyperthyroidism, leading to symptoms such as weight loss, heat intolerance, goiter, and characteristic eye manifestations.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Graves disease canonical | 1 |
| Graves’ disease | 1 |
Statements (63)
| Predicate | Object |
|---|---|
| instanceOf |
autoimmune disease
ⓘ
cause of hyperthyroidism ⓘ endocrine disorder ⓘ thyroid disease ⓘ |
| affectsOrgan | thyroid gland ⓘ |
| alsoKnownAs |
Basedow disease
ⓘ
diffuse toxic goiter ⓘ |
| associatedWith |
HLA-B8
ⓘ
HLA-DR3 ⓘ other autoimmune diseases ⓘ |
| canLeadTo |
atrial fibrillation
ⓘ
heart failure ⓘ osteoporosis ⓘ thyroid storm ⓘ |
| hasCause |
autoimmune reaction against thyroid-stimulating hormone receptor
ⓘ
thyroid-stimulating immunoglobulins ⓘ |
| hasComplication |
compressive optic neuropathy
ⓘ
thyroid storm in untreated hyperthyroidism ⓘ vision loss from severe ophthalmopathy ⓘ |
| hasCourse | chronic ⓘ |
| hasDermatologicManifestation |
hyperpigmentation of shins
ⓘ
pretibial myxedema ⓘ warm moist skin ⓘ |
| hasImagingFinding | diffuse increased radioactive iodine uptake ⓘ |
| hasLaboratoryFinding |
elevated free T3
ⓘ
elevated free T4 ⓘ positive TSH receptor antibodies ⓘ positive thyroid-stimulating immunoglobulins ⓘ suppressed TSH ⓘ |
| hasOcularManifestation |
exophthalmos
ⓘ
lid lag ⓘ ophthalmopathy ⓘ periorbital edema ⓘ |
| hasSign |
bruit over thyroid
ⓘ
diffuse goiter ⓘ |
| hasSymptom |
anxiety
ⓘ
diarrhea ⓘ fatigue ⓘ goiter ⓘ heat intolerance ⓘ increased appetite ⓘ insomnia ⓘ oligomenorrhea ⓘ palpitations ⓘ proximal muscle weakness ⓘ tachycardia ⓘ tremor ⓘ weight loss ⓘ |
| moreCommonIn | women ⓘ |
| namedAfter | Robert J. Graves ⓘ |
| riskFactor |
family history of autoimmune disease
ⓘ
female sex ⓘ pregnancy ⓘ smoking ⓘ stress ⓘ |
| treatedWith |
antithyroid drugs
ⓘ
beta blockers ⓘ glucocorticoids for ophthalmopathy ⓘ methimazole ⓘ propylthiouracil ⓘ radioactive iodine ablation ⓘ thyroidectomy ⓘ |
| typicalOnset | adulthood ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Graves’ disease