pMT1
E357722
pMT1 is a virulence plasmid of Yersinia pestis that carries key genes, including the murine toxin gene, essential for the bacterium’s pathogenicity and flea-borne transmission.
All labels observed (1)
| Label | Occurrences |
|---|---|
| pMT1 canonical | 1 |
Statements (39)
| Predicate | Object |
|---|---|
| instanceOf |
plasmid
ⓘ
virulence plasmid ⓘ |
| associatedWithDisease | plague ⓘ |
| associatedWithPathotype | highly virulent Yersinia pestis strains ⓘ |
| biosafetyRelevance | biodefense and high-consequence pathogen research ⓘ |
| carriersGene |
caf1
ⓘ
fraction 1 capsule antigen gene ⓘ murine toxin gene ⓘ pH 6 antigen gene ⓘ psaA ⓘ ymt ⓘ |
| carriersLocus |
fra locus
ⓘ
ymt locus ⓘ |
| contributesTo |
environmental persistence in flea gut
ⓘ
resistance to phagocytosis via capsule formation ⓘ |
| discoveredInContextOf | plague virulence studies ⓘ |
| DNAType | circular double-stranded DNA ⓘ |
| encodes |
F1 capsule antigen
ⓘ
Yersinia murine toxin ⓘ pH 6 antigen ⓘ |
| foundInTaxon | Yersinia pestis ⓘ |
| geneticElementOf |
Yersinia pestis
ⓘ
surface form:
Yersinia pestis CO92
Yersinia pestis ⓘ
surface form:
Yersinia pestis KIM
|
| hasAlternativeName |
F1 plasmid
ⓘ
pFra ⓘ |
| hostRange | narrow, mainly Yersinia pestis ⓘ |
| importanceInResearch |
model for studying flea-borne transmission mechanisms
ⓘ
target for attenuation in vaccine strain development ⓘ |
| involvedIn |
oral toxicity to rodents
ⓘ
survival of Yersinia pestis in flea vector ⓘ |
| isMobileGeneticElement | true ⓘ |
| isNonChromosomal | true ⓘ |
| location | cytoplasm of Yersinia pestis ⓘ |
| molecularFunctionContext | virulence factor expression platform ⓘ |
| requiredFor |
blockage-dependent flea transmission
ⓘ
efficient colonization of flea midgut ⓘ |
| roleIn |
flea-borne transmission of Yersinia pestis
ⓘ
pathogenicity of Yersinia pestis ⓘ |
| taxonSpecificity | primarily Yersinia pestis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.