Yersinia outer proteins
E357721
Yersinia outer proteins are a group of effector proteins secreted by Yersinia bacteria via a type III secretion system that disrupt host immune responses and promote infection.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Yersinia outer proteins canonical | 1 |
Statements (43)
| Predicate | Object |
|---|---|
| instanceOf |
bacterial effector protein
ⓘ
type III secretion system effector ⓘ virulence factor ⓘ |
| alsoKnownAs | Yops ⓘ |
| component |
YopE
ⓘ
YopH ⓘ YopJ ⓘ YopK ⓘ YopM ⓘ YopN ⓘ YopO ⓘ YopP ⓘ YopQ ⓘ YopT ⓘ YpkA ⓘ |
| encodedBy | Yersinia virulence plasmid pYV ⓘ |
| function |
disrupt host immune responses
ⓘ
induce apoptosis in immune cells ⓘ inhibit inflammatory signaling pathways ⓘ inhibit phagocytosis ⓘ promote bacterial infection ⓘ |
| inhibitionOf |
MAPK signaling pathways
ⓘ
NF-kappaB signaling ⓘ phagocytic uptake by macrophages ⓘ pro-inflammatory cytokine production ⓘ |
| localization |
bacterial cytoplasm before secretion
ⓘ
host cell cytosol after translocation ⓘ |
| producedBy |
Yersinia
ⓘ
surface form:
Yersinia enterocolitica
Yersinia pestis ⓘ Yersinia ⓘ
surface form:
Yersinia pseudotuberculosis
|
| regulation |
induced at 37 degrees Celsius
ⓘ
induced upon host cell contact ⓘ |
| relevance |
potential targets for anti-virulence therapy
ⓘ
used as tools to study host signaling pathways ⓘ |
| roleInDisease |
gastroenteritis caused by Yersinia enterocolitica
ⓘ
mesenteric lymphadenitis ⓘ plague pathogenesis ⓘ |
| secretedBy | type III secretion system ⓘ |
| studiedIn |
immunology
ⓘ
infection biology ⓘ |
| target |
host adaptive immune system
ⓘ
host innate immune system ⓘ |
| transportMechanism | needle-like injectisome ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.