David Sinclair (biologist)
E290015
David Sinclair is an Australian biologist and Harvard Medical School professor best known for his pioneering research on aging, sirtuins, and longevity therapeutics.
All labels observed (3)
| Label | Occurrences |
|---|---|
| David Andrew Sinclair | 1 |
| David Sinclair | 1 |
| David Sinclair (biologist) canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2705657 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: David Sinclair (biologist) Context triple: [Sinclair, hasNotableBearer, David Sinclair (biologist)]
-
A.
Douglas Ainslie
Douglas Ainslie is a mild-mannered, retired British man seeking a new start in India in the film "The Best Exotic Marigold Hotel," portrayed by Bill Nighy.
-
B.
Spencer de Grey
Spencer de Grey is a prominent British architect and senior partner at Foster + Partners, known for his leadership in major international architectural projects.
-
C.
Dr. Jim Bayliss
Dr. Jim Bayliss is a disillusioned physician and neighbor in Arthur Miller’s play "All My Sons," whose moral conflict and cynicism highlight the play’s themes of compromised ideals and social responsibility.
-
D.
Sean B. Carroll
Sean B. Carroll is an evolutionary biologist, author, and science communicator known for his work in evolutionary developmental biology and for popularizing science through award-winning books and media.
-
E.
Sydney Brenner
Sydney Brenner was a pioneering South African biologist and Nobel Prize laureate renowned for his foundational work in molecular biology and the use of C. elegans as a model organism.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: David Sinclair (biologist) Target entity description: David Sinclair is an Australian biologist and Harvard Medical School professor best known for his pioneering research on aging, sirtuins, and longevity therapeutics.
-
A.
Douglas Ainslie
Douglas Ainslie is a mild-mannered, retired British man seeking a new start in India in the film "The Best Exotic Marigold Hotel," portrayed by Bill Nighy.
-
B.
Spencer de Grey
Spencer de Grey is a prominent British architect and senior partner at Foster + Partners, known for his leadership in major international architectural projects.
-
C.
Dr. Jim Bayliss
Dr. Jim Bayliss is a disillusioned physician and neighbor in Arthur Miller’s play "All My Sons," whose moral conflict and cynicism highlight the play’s themes of compromised ideals and social responsibility.
-
D.
Sean B. Carroll
Sean B. Carroll is an evolutionary biologist, author, and science communicator known for his work in evolutionary developmental biology and for popularizing science through award-winning books and media.
-
E.
Sydney Brenner
Sydney Brenner was a pioneering South African biologist and Nobel Prize laureate renowned for his foundational work in molecular biology and the use of C. elegans as a model organism.
- F. None of above. chosen
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
author
ⓘ
biologist ⓘ podcast host ⓘ university professor ⓘ |
| academicDegree | PhD in Molecular Genetics ⓘ |
| authorOf | Lifespan: Why We Age—and Why We Don’t Have To ⓘ |
| awardReceived |
Australian Commonwealth Prize for Science and Innovation
ⓘ
Merck Prize ⓘ Nathan Shock Award ⓘ Time 100 Most Influential People ⓘ
surface form:
TIME 100 Most Influential People (2014)
|
| birthName |
David Sinclair (biologist)
self-linksurface differs
ⓘ
surface form:
David Andrew Sinclair
|
| coFounded |
Cohbar
ⓘ
EdenRoc Sciences ⓘ Genocea Biosciences ⓘ Life Biosciences ⓘ MetroBiotech ⓘ Ovascience ⓘ |
| countryOfCitizenship | Australia ⓘ |
| dateOfBirth | 1969-06-26 ⓘ |
| doctoralAdvisor | Lindsay Wu ⓘ |
| educatedAt | University of New South Wales ⓘ |
| employer | Harvard Medical School ⓘ |
| familyName | Sinclair ⓘ |
| fieldOfWork |
aging research
ⓘ
biology ⓘ epigenetics ⓘ genetics ⓘ gerontology ⓘ longevity therapeutics ⓘ |
| founded | Sirtris Pharmaceuticals ⓘ |
| givenName | David ⓘ |
| hasPodcast |
Lifespan with Dr. David Sinclair
ⓘ
The Sinclair Lab Podcast ⓘ |
| hasResearchLab | Sinclair Lab at Harvard Medical School ⓘ |
| jobTitle | Professor of Genetics ⓘ |
| knownFor |
NAD+ metabolism research
ⓘ
longevity interventions ⓘ research on aging ⓘ research on sirtuins ⓘ |
| languageOfWorkOrName | English ⓘ |
| name |
David Sinclair (biologist)
self-link
ⓘ
surface form:
David Sinclair
|
| notableIdea |
information theory of aging
ⓘ
view of aging as a treatable disease ⓘ |
| notableWork |
demonstrating roles of sirtuins in aging
ⓘ
epigenetic information theory of aging ⓘ studies on resveratrol as a sirtuin activator ⓘ work on NAD+ boosters such as NMN and NR ⓘ |
| placeOfBirth | Sydney ⓘ |
| positionHeld | Co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School ⓘ |
| researchInterest |
DNA damage and repair
ⓘ
NAD+ precursors ⓘ caloric restriction mimetics ⓘ epigenetic reprogramming ⓘ resveratrol ⓘ sirtuin activators ⓘ |
| residence | Boston ⓘ |
| workplace | Harvard Medical School ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: David Sinclair (biologist) Description of subject: David Sinclair is an Australian biologist and Harvard Medical School professor best known for his pioneering research on aging, sirtuins, and longevity therapeutics.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
David Sinclair
this entity surface form:
David Sinclair
subject surface form:
David Sinclair
this entity surface form:
David Andrew Sinclair