rifampicin
E271800
Rifampicin is a broad-spectrum rifamycin antibiotic widely used as a first-line drug in the treatment of tuberculosis and other serious bacterial infections.
All labels observed (1)
| Label | Occurrences |
|---|---|
| rifampicin canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2504159 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: rifampicin Context triple: [Mycobacterium tuberculosis, antibioticTreatment, rifampicin]
-
A.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
-
B.
Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
-
C.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
-
D.
Balemartine
Balemartine is a small coastal village located on the island of Tiree in Scotland’s Inner Hebrides.
-
E.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: rifampicin Target entity description: Rifampicin is a broad-spectrum rifamycin antibiotic widely used as a first-line drug in the treatment of tuberculosis and other serious bacterial infections.
-
A.
amantadine
Amantadine is an antiviral and antiparkinsonian medication used to help manage motor symptoms such as tremor and rigidity in people with Parkinson’s disease.
-
B.
Lamotrek
Lamotrek is a small atoll in the Federated States of Micronesia known for its traditional seafaring culture and navigational expertise.
-
C.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
-
D.
Balemartine
Balemartine is a small coastal village located on the island of Tiree in Scotland’s Inner Hebrides.
-
E.
Darzalex
Darzalex is a monoclonal antibody drug (daratumumab) used primarily in the treatment of multiple myeloma.
- F. None of above. chosen
Statements (58)
| Predicate | Object |
|---|---|
| instanceOf |
antibiotic drug
ⓘ
antitubercular agent ⓘ broad-spectrum antibiotic ⓘ rifamycin antibiotic ⓘ small molecule ⓘ |
| adverseEffect |
elevated liver enzymes
ⓘ
flu-like syndrome ⓘ gastrointestinal disturbances ⓘ hepatotoxicity ⓘ hypersensitivity reactions ⓘ orange-red discoloration of urine, sweat, and tears ⓘ rash ⓘ thrombocytopenia ⓘ |
| approval | introduced into clinical use in the late 1960s ⓘ |
| belongsToDrugClass |
first-line antitubercular drugs
ⓘ
rifamycins ⓘ |
| chemicalFormula | C43H58N4O12 ⓘ |
| color | reddish-brown crystalline powder ⓘ |
| combinationTherapy |
used in combination with isoniazid for tuberculosis
ⓘ
used in combination with isoniazid, pyrazinamide, and ethambutol for tuberculosis ⓘ |
| contraindication |
known hypersensitivity to rifamycins
ⓘ
severe hepatic impairment ⓘ |
| discovery | developed from rifamycin B produced by Streptomyces mediterranei ⓘ |
| drugInteraction |
interacts with many antiretroviral drugs
ⓘ
interacts with oral contraceptives ⓘ interacts with warfarin ⓘ reduces plasma concentrations of many co-administered drugs ⓘ strong inducer of cytochrome P450 enzymes ⓘ |
| halfLife | approximately 2–5 hours in adults ⓘ |
| hasATCCode | J04AB02 ⓘ |
| hasCASNumber | 13292-46-1 ⓘ |
| hasDrugBankID | DB01045 ⓘ |
| hasMolarMass | 822.94 g/mol ⓘ |
| hasPubChemCID | 5381226 ⓘ |
| indication |
brucellosis
ⓘ
endocarditis caused by susceptible organisms ⓘ latent tuberculosis infection ⓘ leprosy ⓘ prophylaxis of Haemophilus influenzae type b infection ⓘ prophylaxis of meningococcal meningitis ⓘ prosthetic joint infections due to staphylococci ⓘ serious staphylococcal infections ⓘ tuberculosis ⓘ |
| mechanismOfAction | inhibits DNA-dependent RNA polymerase in susceptible bacteria ⓘ |
| pharmacokineticProperty |
excreted mainly in bile and feces
ⓘ
metabolized primarily in the liver ⓘ well absorbed orally on an empty stomach ⓘ widely distributed in body tissues and fluids ⓘ |
| pregnancyCategory | Category C (US FDA, historical) ⓘ |
| resistanceMechanism | mutations in rpoB gene encoding RNA polymerase beta subunit ⓘ |
| routeOfAdministration |
intravenous
ⓘ
oral ⓘ |
| spectrumOfActivity |
Mycobacterium leprae
ⓘ
Mycobacterium tuberculosis ⓘ many Gram-positive bacteria ⓘ some Gram-negative bacteria ⓘ |
| synonym | rifampin ⓘ |
| target | bacterial DNA-dependent RNA polymerase beta subunit ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: rifampicin Description of subject: Rifampicin is a broad-spectrum rifamycin antibiotic widely used as a first-line drug in the treatment of tuberculosis and other serious bacterial infections.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.