tryptophan 2,3-dioxygenase
E1159681
UNEXPLORED
Tryptophan 2,3-dioxygenase is a heme-containing enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of tryptophan, playing a key role in tryptophan metabolism and regulation.
All labels observed (1)
| Label | Occurrences |
|---|---|
| tryptophan 2,3-dioxygenase canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T15478651 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: tryptophan 2,3-dioxygenase Context triple: [kynurenine pathway, involvesEnzyme, tryptophan 2,3-dioxygenase]
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A.
aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
-
B.
catechol-O-methyltransferase
Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
-
C.
Tannourine
Tannourine is a mountainous village in northern Lebanon known for its dramatic landscapes, traditional Maronite Christian heritage, and the nearby Tannourine Cedars Forest Nature Reserve.
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D.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
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E.
cytochrome P450 reductase
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: tryptophan 2,3-dioxygenase Target entity description: Tryptophan 2,3-dioxygenase is a heme-containing enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of tryptophan, playing a key role in tryptophan metabolism and regulation.
-
A.
aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
-
B.
catechol-O-methyltransferase
Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
-
C.
Tannourine
Tannourine is a mountainous village in northern Lebanon known for its dramatic landscapes, traditional Maronite Christian heritage, and the nearby Tannourine Cedars Forest Nature Reserve.
-
D.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
E.
cytochrome P450 reductase
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.