Triple

T6003730
Position Surface form Disambiguated ID Type / Status
Subject Loxo Oncology E133655 entity
Predicate leadProductAlsoKnownAs P39 FINISHED
Object LOXO-101
LOXO-101 is a targeted cancer therapy drug candidate developed by Loxo Oncology to inhibit TRK fusion proteins implicated in various tumors.
E564270 NE FINISHED

How this triple was built (5 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: LOXO-101 | Statement: [Loxo Oncology, leadProductAlsoKnownAs, LOXO-101]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: LOXO-101
Context triple: [Loxo Oncology, leadProductAlsoKnownAs, LOXO-101]
  • A. LOXO-305
    LOXO-305 is a highly selective, non-covalent Bruton’s tyrosine kinase (BTK) inhibitor being developed as a targeted therapy for B-cell malignancies such as chronic lymphocytic leukemia.
  • B. LOXO-195
    LOXO-195 is a next-generation, highly selective TRK inhibitor developed to treat cancers that have developed resistance to earlier TRK-targeted therapies.
  • C. LOXO-292
    LOXO-292, also known as selpercatinib, is a targeted cancer therapy that selectively inhibits RET kinase and is used to treat certain RET-altered thyroid and lung cancers.
  • D. LOXO
    LOXO was the stock ticker symbol for Loxo Oncology, a biopharmaceutical company focused on developing targeted cancer therapies before its acquisition.
  • E. Imfinzi
    Imfinzi is a prescription immunotherapy drug (durvalumab) developed by AstraZeneca, primarily used to treat certain types of lung and bladder cancers by helping the immune system attack cancer cells.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: LOXO-101
Triple: [Loxo Oncology, leadProductAlsoKnownAs, LOXO-101]
Generated description
LOXO-101 is a targeted cancer therapy drug candidate developed by Loxo Oncology to inhibit TRK fusion proteins implicated in various tumors.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: LOXO-101
Target entity description: LOXO-101 is a targeted cancer therapy drug candidate developed by Loxo Oncology to inhibit TRK fusion proteins implicated in various tumors.
  • A. LOXO-305
    LOXO-305 is a highly selective, non-covalent Bruton’s tyrosine kinase (BTK) inhibitor being developed as a targeted therapy for B-cell malignancies such as chronic lymphocytic leukemia.
  • B. LOXO-195 chosen
    LOXO-195 is a next-generation, highly selective TRK inhibitor developed to treat cancers that have developed resistance to earlier TRK-targeted therapies.
  • C. LOXO-292
    LOXO-292, also known as selpercatinib, is a targeted cancer therapy that selectively inhibits RET kinase and is used to treat certain RET-altered thyroid and lung cancers.
  • D. LOXO
    LOXO was the stock ticker symbol for Loxo Oncology, a biopharmaceutical company focused on developing targeted cancer therapies before its acquisition.
  • E. Imfinzi
    Imfinzi is a prescription immunotherapy drug (durvalumab) developed by AstraZeneca, primarily used to treat certain types of lung and bladder cancers by helping the immune system attack cancer cells.
  • F. None of above.
PD Predicate disambiguation gpt-5-mini-2025-08-07
Target predicate: leadProductAlsoKnownAs
Context triple: [Loxo Oncology, leadProductAlsoKnownAs, LOXO-101]
  • A. associatedCompanyMainProductLine
    Indicates that a company’s primary or main line of products is linked or related to a specified product category or product line.
  • B. marketingNameOf
    Indicates that one entity is the marketing or brand name used to promote or refer to another entity.
  • C. tradeNameIncludes
    Indicates that a trade name contains another name or term as part of its full designation.
  • D. relatedBrand
    Indicates a relationship where one brand is associated with, connected to, or otherwise related to another brand.
  • E. alsoKnownAs chosen
    Indicates that one entity is an alternative name, alias, or designation for another entity.
  • F. None of above.

Provenance (6 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69c00872444c8190bfaf1739dcec765c completed March 22, 2026, 3:19 p.m.
NER Named-entity recognition batch_69c04f0f63148190826198281dce3713 completed March 22, 2026, 8:20 p.m.
NED1 Entity disambiguation (via context triple) batch_69c1250c82588190af8102263c1bd242 completed March 23, 2026, 11:33 a.m.
NEDg Description generation batch_69c125968c70819096266bcf0413a941 completed March 23, 2026, 11:35 a.m.
NED2 Entity disambiguation (via description) batch_69c126070ba08190bc26e61c2c519b50 completed March 23, 2026, 11:37 a.m.
PD Predicate disambiguation batch_69c049e3316c819087ea635fa7ee8472 completed March 22, 2026, 7:58 p.m.
Created at: March 22, 2026, 4:06 p.m.