Triple
T6003721
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | Loxo Oncology |
E133655
|
entity |
| Predicate | developedDrug |
P73
|
FINISHED |
| Object |
larotrectinib
Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
|
E561035
|
NE FINISHED |
How this triple was built (5 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: larotrectinib | Statement: [Loxo Oncology, developedDrug, larotrectinib]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: larotrectinib Context triple: [Loxo Oncology, developedDrug, larotrectinib]
-
A.
Imfinzi
Imfinzi is a prescription immunotherapy drug (durvalumab) developed by AstraZeneca, primarily used to treat certain types of lung and bladder cancers by helping the immune system attack cancer cells.
-
B.
Lynparza
Lynparza is a targeted cancer therapy (a PARP inhibitor) used primarily to treat certain types of ovarian, breast, pancreatic, and prostate cancers associated with BRCA mutations.
-
C.
Verzenio
Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
-
D.
Inflectra
Inflectra is a biosimilar monoclonal antibody to infliximab used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
E.
Ibrance
Ibrance is a targeted oral cancer medication (palbociclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg
Description generation
gpt-5.1
Instruction
Generate a one-sentence description of the target entity. You are given a context triple in the form (subject, predicate, object), where the object is the target entity. # Instructions Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. Avoid repeating the information from the triple, unless really essential. # Response Format Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: larotrectinib Triple: [Loxo Oncology, developedDrug, larotrectinib]
Generated description
Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: larotrectinib Target entity description: Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
-
A.
Imfinzi
Imfinzi is a prescription immunotherapy drug (durvalumab) developed by AstraZeneca, primarily used to treat certain types of lung and bladder cancers by helping the immune system attack cancer cells.
-
B.
Lynparza
Lynparza is a targeted cancer therapy (a PARP inhibitor) used primarily to treat certain types of ovarian, breast, pancreatic, and prostate cancers associated with BRCA mutations.
-
C.
Verzenio
Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
-
D.
Inflectra
Inflectra is a biosimilar monoclonal antibody to infliximab used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
E.
Ibrance
Ibrance is a targeted oral cancer medication (palbociclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer.
- F. None of above. chosen
PD
Predicate disambiguation
gpt-5-mini-2025-08-07
Target predicate: developedDrug Context triple: [Loxo Oncology, developedDrug, larotrectinib]
-
A.
isFirstDrugApprovedFor
Indicates that a drug is the earliest or original medication approved for treating a particular condition, disease, or indication.
-
B.
isProdrugOf
Indicates that one substance is a precursor form that is metabolized in the body to produce the active form of another substance.
-
C.
developed
chosen
Indicates that one entity created, designed, or brought another entity into a more advanced or complete state through effort or work.
-
D.
approvedDrugForm
Indicates that a particular pharmaceutical form (e.g., tablet, injection) is an officially approved formulation of a given drug.
-
E.
evaluatesDrug
Indicates that an entity assesses or judges the properties, effectiveness, or impact of a drug.
- F. None of above.
Provenance (6 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69c00872444c8190bfaf1739dcec765c |
completed | March 22, 2026, 3:19 p.m. |
| NER | Named-entity recognition | batch_69c04f0f63148190826198281dce3713 |
completed | March 22, 2026, 8:20 p.m. |
| NED1 | Entity disambiguation (via context triple) | batch_69c1088f5c84819094e4696c24c4dd79 |
completed | March 23, 2026, 9:31 a.m. |
| NEDg | Description generation | batch_69c1099f00f88190a5f1f0fafbb679c2 |
completed | March 23, 2026, 9:36 a.m. |
| NED2 | Entity disambiguation (via description) | batch_69c10a2ffdcc8190bfeebc59d98b2b29 |
completed | March 23, 2026, 9:38 a.m. |
| PD | Predicate disambiguation | batch_69c049e3316c819087ea635fa7ee8472 |
completed | March 22, 2026, 7:58 p.m. |
Created at: March 22, 2026, 4:06 p.m.