Triple

T6003721
Position Surface form Disambiguated ID Type / Status
Subject Loxo Oncology E133655 entity
Predicate developedDrug P73 FINISHED
Object larotrectinib
Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
E561035 NE FINISHED

How this triple was built (5 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: larotrectinib | Statement: [Loxo Oncology, developedDrug, larotrectinib]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: larotrectinib
Context triple: [Loxo Oncology, developedDrug, larotrectinib]
  • A. Imfinzi
    Imfinzi is a prescription immunotherapy drug (durvalumab) developed by AstraZeneca, primarily used to treat certain types of lung and bladder cancers by helping the immune system attack cancer cells.
  • B. Lynparza
    Lynparza is a targeted cancer therapy (a PARP inhibitor) used primarily to treat certain types of ovarian, breast, pancreatic, and prostate cancers associated with BRCA mutations.
  • C. Verzenio
    Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
  • D. Inflectra
    Inflectra is a biosimilar monoclonal antibody to infliximab used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
  • E. Ibrance
    Ibrance is a targeted oral cancer medication (palbociclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: larotrectinib
Triple: [Loxo Oncology, developedDrug, larotrectinib]
Generated description
Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: larotrectinib
Target entity description: Larotrectinib is a targeted cancer therapy that selectively inhibits TRK fusion proteins and is used to treat solid tumors harboring NTRK gene fusions regardless of tumor site.
  • A. Imfinzi
    Imfinzi is a prescription immunotherapy drug (durvalumab) developed by AstraZeneca, primarily used to treat certain types of lung and bladder cancers by helping the immune system attack cancer cells.
  • B. Lynparza
    Lynparza is a targeted cancer therapy (a PARP inhibitor) used primarily to treat certain types of ovarian, breast, pancreatic, and prostate cancers associated with BRCA mutations.
  • C. Verzenio
    Verzenio is a prescription cancer medication (abemaciclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative breast cancer.
  • D. Inflectra
    Inflectra is a biosimilar monoclonal antibody to infliximab used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
  • E. Ibrance
    Ibrance is a targeted oral cancer medication (palbociclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer.
  • F. None of above. chosen
PD Predicate disambiguation gpt-5-mini-2025-08-07
Target predicate: developedDrug
Context triple: [Loxo Oncology, developedDrug, larotrectinib]
  • A. isFirstDrugApprovedFor
    Indicates that a drug is the earliest or original medication approved for treating a particular condition, disease, or indication.
  • B. isProdrugOf
    Indicates that one substance is a precursor form that is metabolized in the body to produce the active form of another substance.
  • C. developed chosen
    Indicates that one entity created, designed, or brought another entity into a more advanced or complete state through effort or work.
  • D. approvedDrugForm
    Indicates that a particular pharmaceutical form (e.g., tablet, injection) is an officially approved formulation of a given drug.
  • E. evaluatesDrug
    Indicates that an entity assesses or judges the properties, effectiveness, or impact of a drug.
  • F. None of above.

Provenance (6 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69c00872444c8190bfaf1739dcec765c completed March 22, 2026, 3:19 p.m.
NER Named-entity recognition batch_69c04f0f63148190826198281dce3713 completed March 22, 2026, 8:20 p.m.
NED1 Entity disambiguation (via context triple) batch_69c1088f5c84819094e4696c24c4dd79 completed March 23, 2026, 9:31 a.m.
NEDg Description generation batch_69c1099f00f88190a5f1f0fafbb679c2 completed March 23, 2026, 9:36 a.m.
NED2 Entity disambiguation (via description) batch_69c10a2ffdcc8190bfeebc59d98b2b29 completed March 23, 2026, 9:38 a.m.
PD Predicate disambiguation batch_69c049e3316c819087ea635fa7ee8472 completed March 22, 2026, 7:58 p.m.
Created at: March 22, 2026, 4:06 p.m.