Triple

T36599452
Position Surface form Disambiguated ID Type / Status
Subject tucatinib E902879 entity
Predicate instanceOf P0 FINISHED
Object small-molecule tyrosine kinase inhibitor C43617 CONCEPT FINISHED

How this triple was built (1 step)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

CD Concept disambiguation gpt-5-mini-2025-08-07 
Target class: small-molecule tyrosine kinase inhibitor
Context triple: [tucatinib, instanceOf, small-molecule tyrosine kinase inhibitor]
  • A. tyrosine kinase inhibitor chosen
    A tyrosine kinase inhibitor is a drug that blocks the activity of tyrosine kinases—enzymes involved in cell signaling pathways—to prevent uncontrolled cell growth and proliferation, commonly used in cancer therapy.
  • B. EGFR inhibitor
    An EGFR inhibitor is a drug that blocks the epidermal growth factor receptor signaling pathway to slow or stop the growth of cancer cells that depend on this receptor.
  • C. CDK4/6 inhibitor
    A CDK4/6 inhibitor is a targeted anticancer drug that blocks cyclin-dependent kinases 4 and 6 to halt cell cycle progression from G1 to S phase, thereby inhibiting tumor cell proliferation.
  • D. IGF-1R inhibitor
    An IGF-1R inhibitor is a drug that blocks the insulin-like growth factor 1 receptor to reduce signaling pathways that promote cell growth, survival, and proliferation, particularly in cancer cells.
  • E. receptor tyrosine kinase
    A receptor tyrosine kinase is a transmembrane protein that, upon binding an extracellular ligand, dimerizes and autophosphorylates its intracellular tyrosine residues to initiate intracellular signaling cascades regulating cell growth, differentiation, and survival.
  • F. None of above.

Provenance (1 batch)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69f76e66b7b88190848f7a3e1188915f completed May 3, 2026, 3:48 p.m.
Created at: May 3, 2026, 4:11 p.m.