Triple

T15982906
Position Surface form Disambiguated ID Type / Status
Subject Vertex Pharmaceuticals E387617 entity
Predicate hasClinicalProgram P6928 FINISHED
Object exagamglogene autotemcel
Exagamglogene autotemcel is an investigational CRISPR/Cas9-based gene-editing therapy being developed to treat inherited blood disorders such as sickle cell disease and transfusion-dependent beta thalassemia.
E1188107 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: exagamglogene autotemcel | Statement: [Vertex Pharmaceuticals, hasClinicalProgram, exagamglogene autotemcel]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: exagamglogene autotemcel
Context triple: [Vertex Pharmaceuticals, hasClinicalProgram, exagamglogene autotemcel]
  • A. Kymriah
    Kymriah is a pioneering CAR-T cell therapy used to treat certain types of blood cancers by genetically modifying a patient’s own immune cells to target and destroy malignant cells.
  • B. onasemnogene abeparvovec
    Onasemnogene abeparvovec is a gene therapy medication that delivers a functional copy of the SMN1 gene to treat infants and young children with certain forms of spinal muscular atrophy.
  • C. AveXis
    AveXis is a biotechnology company best known for developing the gene therapy onasemnogene abeparvovec (Zolgensma) for spinal muscular atrophy.
  • D. daratumumab
    Daratumumab is a monoclonal antibody drug used primarily to treat multiple myeloma by targeting and destroying malignant plasma cells.
  • E. isatuximab
    Isatuximab is a monoclonal antibody drug used primarily in the treatment of multiple myeloma by targeting and killing malignant plasma cells.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: exagamglogene autotemcel
Triple: [Vertex Pharmaceuticals, hasClinicalProgram, exagamglogene autotemcel]
Generated description
Exagamglogene autotemcel is an investigational CRISPR/Cas9-based gene-editing therapy being developed to treat inherited blood disorders such as sickle cell disease and transfusion-dependent beta thalassemia.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: exagamglogene autotemcel
Target entity description: Exagamglogene autotemcel is an investigational CRISPR/Cas9-based gene-editing therapy being developed to treat inherited blood disorders such as sickle cell disease and transfusion-dependent beta thalassemia.
  • A. Kymriah
    Kymriah is a pioneering CAR-T cell therapy used to treat certain types of blood cancers by genetically modifying a patient’s own immune cells to target and destroy malignant cells.
  • B. onasemnogene abeparvovec
    Onasemnogene abeparvovec is a gene therapy medication that delivers a functional copy of the SMN1 gene to treat infants and young children with certain forms of spinal muscular atrophy.
  • C. AveXis
    AveXis is a biotechnology company best known for developing the gene therapy onasemnogene abeparvovec (Zolgensma) for spinal muscular atrophy.
  • D. daratumumab
    Daratumumab is a monoclonal antibody drug used primarily to treat multiple myeloma by targeting and destroying malignant plasma cells.
  • E. isatuximab
    Isatuximab is a monoclonal antibody drug used primarily in the treatment of multiple myeloma by targeting and killing malignant plasma cells.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d86da94ccc819083d187f5dc6a123e completed April 10, 2026, 3:25 a.m.
NER Named-entity recognition batch_69e15755b5548190acfa29eecb11e675 completed April 16, 2026, 9:40 p.m.
NED1 Entity disambiguation (via context triple) batch_69ffc3cdf7848190848e9081027dc027 completed May 9, 2026, 11:31 p.m.
NEDg Description generation batch_69ffc5669c1c81909bacf61c96cb7816 completed May 9, 2026, 11:38 p.m.
NED2 Entity disambiguation (via description) batch_69ffc5c7db1c8190b4e1de6f6e3ce8a0 completed May 9, 2026, 11:39 p.m.
Created at: April 10, 2026, 4:54 a.m.