Triple

T15478584
Position Surface form Disambiguated ID Type / Status
Subject NAD+ E376853 entity
Predicate isSubstrateOf P37222 FINISHED
Object isocitrate dehydrogenase (NAD+-dependent)
Isocitrate dehydrogenase (NAD+-dependent) is a key metabolic enzyme in the citric acid cycle that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while reducing NAD+ to NADH.
 E1159677 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: isocitrate dehydrogenase (NAD+-dependent) | Statement: [NAD+, isSubstrateOf, isocitrate dehydrogenase (NAD+-dependent)]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07 
Target entity: isocitrate dehydrogenase (NAD+-dependent)
Context triple: [NAD+, isSubstrateOf, isocitrate dehydrogenase (NAD+-dependent)]
  • A. NADPH
    NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
  • B. glycinamide ribonucleotide formyltransferase
    Glycinamide ribonucleotide formyltransferase is a key enzyme in the de novo purine biosynthesis pathway that catalyzes a formylation step essential for nucleotide production and is targeted by certain anticancer drugs.
  • C. cytochrome P450 reductase
    Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
  • D. Malate
    Malate is a historic coastal district of Manila, Philippines, known for its nightlife, cultural landmarks, and proximity to Manila Bay.
  • E. aromatic L-amino acid decarboxylase
    Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: isocitrate dehydrogenase (NAD+-dependent)
Triple: [NAD+, isSubstrateOf, isocitrate dehydrogenase (NAD+-dependent)]
Generated description
Isocitrate dehydrogenase (NAD+-dependent) is a key metabolic enzyme in the citric acid cycle that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while reducing NAD+ to NADH.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07 
Target entity: isocitrate dehydrogenase (NAD+-dependent)
Target entity description: Isocitrate dehydrogenase (NAD+-dependent) is a key metabolic enzyme in the citric acid cycle that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while reducing NAD+ to NADH.
  • A. NADPH
    NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
  • B. glycinamide ribonucleotide formyltransferase
    Glycinamide ribonucleotide formyltransferase is a key enzyme in the de novo purine biosynthesis pathway that catalyzes a formylation step essential for nucleotide production and is targeted by certain anticancer drugs.
  • C. cytochrome P450 reductase
    Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
  • D. Malate
    Malate is a historic coastal district of Manila, Philippines, known for its nightlife, cultural landmarks, and proximity to Manila Bay.
  • E. aromatic L-amino acid decarboxylase
    Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d85cd21dcc81908646251b1c26ea00 completed April 10, 2026, 2:13 a.m.
NER Named-entity recognition batch_69e03f8a77a081909f12f13660452f4a completed April 16, 2026, 1:46 a.m.
NED1 Entity disambiguation (via context triple) batch_69ff2d0b3e7881908f195701fe222371 completed May 9, 2026, 12:48 p.m.
NEDg Description generation batch_69ff2e4010dc8190b0f81d03acf8ba41 completed May 9, 2026, 12:53 p.m.
NED2 Entity disambiguation (via description) batch_69ff310c2d5c819093295c45307176ec completed May 9, 2026, 1:05 p.m.
Created at: April 10, 2026, 3:34 a.m.