Triple

T10214776
Position Surface form Disambiguated ID Type / Status
Subject CYP3A4 E242412 entity
Predicate inhibitedBy P37861 FINISHED
Object ketoconazole
Ketoconazole is an imidazole antifungal medication that inhibits ergosterol synthesis and strongly blocks CYP3A4-mediated drug metabolism.
E850010 NE FINISHED

How this triple was built (5 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: ketoconazole | Statement: [CYP3A4, inhibitedBy, ketoconazole]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: ketoconazole
Context triple: [CYP3A4, inhibitedBy, ketoconazole]
  • A. fluconazole
    Fluconazole is a triazole antifungal medication commonly used to treat and prevent a wide range of Candida infections in humans.
  • B. voriconazole
    Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
  • C. posaconazole
    Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
  • D. amphotericin B
    Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
  • E. Kotramide
    Kotramide was a medieval Armenian noblewoman known primarily as the wife of King Ashot I Bagratuni, the first king of the Bagratid Kingdom of Armenia.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: ketoconazole
Triple: [CYP3A4, inhibitedBy, ketoconazole]
Generated description
Ketoconazole is an imidazole antifungal medication that inhibits ergosterol synthesis and strongly blocks CYP3A4-mediated drug metabolism.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: ketoconazole
Target entity description: Ketoconazole is an imidazole antifungal medication that inhibits ergosterol synthesis and strongly blocks CYP3A4-mediated drug metabolism.
  • A. fluconazole
    Fluconazole is a triazole antifungal medication commonly used to treat and prevent a wide range of Candida infections in humans.
  • B. voriconazole
    Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
  • C. posaconazole
    Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
  • D. amphotericin B
    Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
  • E. Kotramide
    Kotramide was a medieval Armenian noblewoman known primarily as the wife of King Ashot I Bagratuni, the first king of the Bagratid Kingdom of Armenia.
  • F. None of above. chosen
PD Predicate disambiguation gpt-5-mini-2025-08-07
Target predicate: inhibitedBy
Context triple: [CYP3A4, inhibitedBy, ketoconazole]
  • A. inhibits chosen
    Indicates that one entity prevents, restrains, or reduces the activity, effect, or occurrence of another entity.
  • B. airedIn
    Indicates that a media work was broadcast or shown during a specific time period or in a particular airing context.
  • C. suppressedIn
    Indicates that one entity’s presence, activity, or expression is reduced, inhibited, or prevented by another entity or condition.
  • D. prohibits
    Indicates that one entity forbids or disallows another entity from performing a specific action or being in a certain state.
  • E. forcedBy
    Indicates that an entity is compelled or coerced into an action or state by another entity.
  • F. None of above.

Provenance (6 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69d381ae26c48190985abd0e25ee5d04 completed April 6, 2026, 9:49 a.m.
NER Named-entity recognition batch_69d3aa273bdc8190bc4cf67a7923cebc completed April 6, 2026, 12:42 p.m.
NED1 Entity disambiguation (via context triple) batch_69d652ea80dc81908bc65ee2ec390467 completed April 8, 2026, 1:06 p.m.
NEDg Description generation batch_69d657818b008190a24170717cff53b9 completed April 8, 2026, 1:26 p.m.
NED2 Entity disambiguation (via description) batch_69d65835a11c819083d069ab0f644d4c completed April 8, 2026, 1:29 p.m.
PD Predicate disambiguation batch_69d39559e5ac8190b88eca75956b7e6a completed April 6, 2026, 11:13 a.m.
Created at: April 6, 2026, 11:04 a.m.