lossOfFunctionLeadsTo
P149298
predicate
Indicates that when the function of one entity is reduced or eliminated, it causes or results in a specific effect or outcome in another entity or system.
All labels observed (2)
| Label | Occurrences |
|---|---|
| lossOfFunctionLeadsTo canonical | 5 |
| dysfunctionLeadsTo | 1 |
Description generation (PDg)
The one-sentence description above was generated by prompting gpt-5.1 with the predicate name and this instruction.
Instruction
Given a predicate that represents a relationship or action between entities, generate a one-sentence description explaining its meaning. # Instructions Focus on describing the relationship, not the entities themselves. # Response Format Begin the description with \' Indicates...\'
Input
Predicate: lossOfFunctionLeadsTo
Generated description
Indicates that when the function of one entity is reduced or eliminated, it causes or results in a specific effect or outcome in another entity or system.
Sample triples (6)
| Subject | Object |
|---|---|
|
SMN1 gene
surface form:
SMN1
|
reduced SMN protein levels ⓘ |
|
SMN1 gene
surface form:
SMN1
|
degeneration of alpha motor neurons ⓘ |
| SMCR8 | impaired autophagy ⓘ |
| SMCR8 | abnormal lysosomal accumulation ⓘ |
| SMCR8 | altered mTORC1 signaling ⓘ |
| Nav1.1 sodium channel | network hyperexcitability via predicate surface "dysfunctionLeadsTo" ⓘ |