Nav1.1 sodium channel
E874308
The Nav1.1 sodium channel is a voltage-gated ion channel in neurons whose dysfunction is strongly implicated in severe epileptic disorders such as Dravet syndrome.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Nav1.1 sodium channel canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10609957 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Nav1.1 sodium channel Context triple: [Dravet syndrome, affectsProtein, Nav1.1 sodium channel]
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A.
Opsanus tau
Opsanus tau, commonly known as the oyster toadfish, is a bottom-dwelling marine fish of the western Atlantic noted for its croaking sounds and ability to thrive in polluted, low-oxygen environments.
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B.
Lamaline
Lamaline is a small coastal town located on the Burin Peninsula in Newfoundland and Labrador, Canada, known historically for its fishing and maritime heritage.
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C.
Takic
Takic is a branch of the Uto-Aztecan language family comprising several closely related Indigenous languages historically spoken in Southern California.
-
D.
Nutisal
Nutisal is a snack brand known for its range of dry-roasted and flavored nut products, owned by the Swedish confectionery company Cloetta.
-
E.
Naux
Naux was a guitarist known for his work with the influential New York punk band Richard Hell and the Voidoids.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Nav1.1 sodium channel Target entity description: The Nav1.1 sodium channel is a voltage-gated ion channel in neurons whose dysfunction is strongly implicated in severe epileptic disorders such as Dravet syndrome.
-
A.
Opsanus tau
Opsanus tau, commonly known as the oyster toadfish, is a bottom-dwelling marine fish of the western Atlantic noted for its croaking sounds and ability to thrive in polluted, low-oxygen environments.
-
B.
Lamaline
Lamaline is a small coastal town located on the Burin Peninsula in Newfoundland and Labrador, Canada, known historically for its fishing and maritime heritage.
-
C.
Takic
Takic is a branch of the Uto-Aztecan language family comprising several closely related Indigenous languages historically spoken in Southern California.
-
D.
Nutisal
Nutisal is a snack brand known for its range of dry-roasted and flavored nut products, owned by the Swedish confectionery company Cloetta.
-
E.
Naux
Naux was a guitarist known for his work with the influential New York punk band Richard Hell and the Voidoids.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
ion channel
ⓘ
membrane protein ⓘ voltage-gated sodium channel ⓘ |
| associatedWithDisease |
Dravet syndrome
NERFINISHED
ⓘ
epileptic encephalopathy ⓘ familial hemiplegic migraine type 3 ⓘ febrile seizures ⓘ generalized epilepsy with febrile seizures plus ⓘ severe myoclonic epilepsy of infancy ⓘ |
| associatedWithPhenotype | temperature-sensitive seizures in Dravet syndrome ⓘ |
| belongsToFamily |
Nav1 family
NERFINISHED
ⓘ
voltage-gated sodium channel alpha subunits ⓘ |
| chromosomalLocationOfGene | 2q24.3 ⓘ |
| dysfunctionLeadsTo | network hyperexcitability ⓘ |
| dysfunctionMechanism | impaired firing of inhibitory interneurons ⓘ |
| encodedBy | SCN1A gene NERFINISHED ⓘ |
| expressedIn | central nervous system ⓘ |
| gatedBy | membrane voltage ⓘ |
| hasAlternativeName |
NaV1.1
NERFINISHED
ⓘ
Nav1.1 NERFINISHED ⓘ SCN1A protein NERFINISHED ⓘ |
| hasBiologicalProcess |
action potential generation
ⓘ
regulation of neuronal excitability ⓘ synaptic transmission ⓘ |
| hasDomain |
pore-forming domain
ⓘ
voltage-sensing domain ⓘ |
| hasFunction |
initiates and propagates action potentials
ⓘ
mediates voltage-dependent sodium ion influx in neurons ⓘ |
| hasMolecularFunction |
sodium ion transmembrane transporter activity
ⓘ
voltage-gated sodium channel activity ⓘ |
| hasSystematicName | sodium channel protein type 1 subunit alpha NERFINISHED ⓘ |
| hasTransmembraneSegments | four domains each with six transmembrane segments ⓘ |
| highlyExpressedIn | GABAergic inhibitory interneurons ⓘ |
| inactivatedBy | fast inactivation gate ⓘ |
| isTargetOf | antiepileptic drug research ⓘ |
| locatedIn |
axon initial segment
ⓘ
neuronal plasma membrane ⓘ nodes of Ranvier NERFINISHED ⓘ |
| mutationTypeAssociated |
frameshift mutations
ⓘ
loss-of-function mutations ⓘ missense mutations ⓘ nonsense mutations ⓘ splice-site mutations ⓘ |
| orthologFoundIn |
mouse
ⓘ
rat ⓘ zebrafish NERFINISHED ⓘ |
| playsRoleIn | inhibitory neurotransmission ⓘ |
| selectiveFor | Na+ ions ⓘ |
| subunitComposition | alpha subunit with four homologous domains ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Nav1.1 sodium channel Description of subject: The Nav1.1 sodium channel is a voltage-gated ion channel in neurons whose dysfunction is strongly implicated in severe epileptic disorders such as Dravet syndrome.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.