all-or-none principle in nerve excitation

E97828

neurophysiological concept physiological principle

The all-or-none principle in nerve excitation is the physiological rule that a nerve fiber, once stimulated beyond a certain threshold, responds with a full, uniform action potential rather than a graded response.

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Statements (44)

Predicate	Object
instanceOf	neurophysiological concept ⓘ physiological principle ⓘ
appliesTo	action potentials ⓘ cardiac muscle fibers ⓘ nerve fibers ⓘ neurons ⓘ skeletal muscle fibers ⓘ
associatedWith	Edgar Adrian ⓘ Hermann von Helmholtz ⓘ
clarifiesThat	response magnitude of a single axon is not proportional to stimulus strength above threshold ⓘ
contrastsWith	electrotonic potentials ⓘ graded potentials ⓘ
dependsOn	reaching a critical level of depolarization ⓘ regenerative opening of sodium channels ⓘ
describes	response of a nerve fiber to stimulation ⓘ
doesNotImply	all neurons in a nerve trunk fire simultaneously ⓘ
hasConsequence	nerve impulses are stereotyped events ⓘ signal reliability along the axon is increased ⓘ
holdsFor	individual axons ⓘ
implies	information about stimulus intensity is encoded in firing frequency rather than spike size ⓘ stronger suprathreshold stimuli do not increase action potential amplitude ⓘ
isBasisFor	uniform size of action potentials in a given axon ⓘ
isDemonstratedBy	recordings of single-axon action potentials ⓘ stimulus–response curves showing threshold behavior ⓘ
isFundamentalTo	Hodgkin–Huxley model ⓘ surface form: Hodgkin–Huxley model of the action potential classical nerve physiology ⓘ
isObservedIn	myelinated axons ⓘ unmyelinated axons ⓘ
isRelatedTo	refractory period of neurons ⓘ safety factor for conduction ⓘ
isSometimesMisinterpretedAs	all cells in a tissue firing together ⓘ
isTaughtIn	cellular neuroscience ⓘ medical physiology ⓘ neurophysiology ⓘ
relatesTo	membrane excitability ⓘ nerve impulse conduction ⓘ threshold potential ⓘ
reliesOn	positive feedback of sodium influx ⓘ voltage-gated sodium channels ⓘ
statesThat	a nerve fiber responds with a full action potential once threshold is reached ⓘ action potential amplitude is not graded with stimulus strength above threshold ⓘ subthreshold stimuli do not produce an action potential ⓘ
usedToExplain	binary nature of neuronal spiking ⓘ uniform conduction of nerve impulses ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

Emil du Bois-Reymond → knownFor → all-or-none principle in nerve excitation ⓘ