LGS
E939685
LGS is a severe, childhood-onset epileptic encephalopathy characterized by multiple types of seizures, cognitive impairment, and a distinctive EEG pattern.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Lennox–Gastaut syndrome | 0 |
Statements (53)
| Predicate | Object |
|---|---|
| instanceOf |
epileptic encephalopathy
ⓘ
neurological disorder ⓘ rare disease ⓘ |
| affects |
both males and females
ⓘ
children ⓘ |
| canBeIdiopathic | true ⓘ |
| hasAbbreviation | LGS NERFINISHED ⓘ |
| hasCause |
central nervous system infections
ⓘ
cortical malformations ⓘ genetic disorders ⓘ hypoxic–ischemic encephalopathy ⓘ perinatal brain injury ⓘ structural brain abnormalities ⓘ tuberous sclerosis complex NERFINISHED ⓘ |
| hasCourse |
chronic
ⓘ
treatment-resistant ⓘ |
| hasEEGPattern |
paroxysmal fast activity in sleep
ⓘ
slow spike-and-wave discharges ⓘ |
| hasICD10Code | G40.4 ⓘ |
| hasIncidence | rare ⓘ |
| hasOnset | childhood ⓘ |
| hasPrognosis |
high risk of persistent seizures into adulthood
ⓘ
often poor ⓘ |
| hasSeizureType |
atonic seizures
ⓘ
atypical absence seizures ⓘ focal seizures ⓘ generalized tonic–clonic seizures ⓘ myoclonic seizures ⓘ tonic seizures ⓘ |
| hasSymptom |
behavioral problems
ⓘ
developmental delay ⓘ frequent falls due to drop attacks ⓘ intellectual disability ⓘ |
| isAssociatedWith |
autism spectrum disorder
ⓘ
behavioral dysregulation ⓘ sleep disturbances ⓘ status epilepticus ⓘ |
| isCharacterizedBy |
cognitive impairment
ⓘ
distinctive EEG pattern ⓘ multiple seizure types ⓘ |
| isTreatedWith |
cannabidiol
ⓘ
clobazam ⓘ corpus callosotomy ⓘ felbamate ⓘ ketogenic diet ⓘ lamotrigine ⓘ rufinamide NERFINISHED ⓘ topiramate ⓘ vagus nerve stimulation ⓘ valproate ⓘ |
| namedAfter |
Henri Gastaut
NERFINISHED
ⓘ
William G. Lennox NERFINISHED ⓘ |
| typicalAgeOfOnset | between 3 and 5 years ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.