rat Cnr2
E939679
Rat Cnr2 is the rat gene encoding the cannabinoid receptor type 2 (CB2), a G protein–coupled receptor involved in modulating immune and inflammatory responses.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
gene
ⓘ
protein-coding gene ⓘ |
| associatedProtein | CB2 GENERATED ⓘ |
| associatedWith |
anti-inflammatory effects
ⓘ
immunomodulation ⓘ |
| biologicalProcess |
G protein–coupled receptor signaling pathway
ⓘ
immune response modulation ⓘ inflammatory response modulation ⓘ neuroinflammatory response ⓘ regulation of cytokine production ⓘ regulation of pain perception ⓘ signal transduction ⓘ |
| cellularLocation |
cell surface
ⓘ
plasma membrane ⓘ |
| couplesTo | Gi/o proteins ⓘ |
| effectOfActivation |
decrease in intracellular cAMP levels
ⓘ
inhibition of adenylyl cyclase ⓘ modulation of ion channel activity ⓘ |
| encodes |
CB2 receptor
NERFINISHED
ⓘ
cannabinoid receptor type 2 ⓘ |
| expressedIn |
B lymphocytes
NERFINISHED
ⓘ
immune cells ⓘ lymph nodes ⓘ macrophages ⓘ microglia ⓘ spleen ⓘ |
| fullName | cannabinoid receptor 2 (macrophage) NERFINISHED ⓘ |
| geneSymbol | Cnr2 ⓘ |
| ligand |
2-arachidonoylglycerol
ⓘ
anandamide ⓘ endocannabinoids ⓘ synthetic cannabinoid agonists ⓘ |
| locatedIn | rat genome ⓘ |
| molecularFunction |
G protein–coupled receptor activity
ⓘ
GTPase activity modulation via G proteins ⓘ cannabinoid receptor activity ⓘ |
| organism | Rattus norvegicus NERFINISHED ⓘ |
| orthologOf |
human CNR2
ⓘ
mouse Cnr2 ⓘ |
| pathway | endocannabinoid signaling pathway ⓘ |
| receptorType |
G protein–coupled receptor
ⓘ
class A rhodopsin-like GPCR ⓘ |
| relatedTo |
endocannabinoid system
ⓘ
pain and inflammation pathways ⓘ |
| species | rat ⓘ |
| targetOf |
cannabinoid receptor agonists
ⓘ
cannabinoid receptor antagonists ⓘ |
| usedIn |
rat models of inflammation
ⓘ
rat models of neuropathic pain ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.