Toxicology in the 21st Century program

E93888

U.S. federal research initiative research program

The Toxicology in the 21st Century program is a U.S. research initiative that uses modern high-throughput and computational methods to improve the prediction of chemical toxicity and reduce reliance on traditional animal testing.

Jump to: Surface forms Statements Referenced by

Observed surface forms (1)

Surface form	Occurrences
Tox21	1

Statements (43)

Predicate	Object
instanceOf	U.S. federal research initiative ⓘ research program ⓘ
aimsTo	develop alternative test methods to animal studies ⓘ identify potential toxic effects earlier in the chemical evaluation process ⓘ prioritize chemicals for further testing ⓘ
beneficiary	chemical safety assessors ⓘ public health decision-makers ⓘ regulatory agencies ⓘ
coordinatedBy	National Center for Advancing Translational Sciences NERFINISHED ⓘ National Human Genome Research Institute ⓘ National Institute of Environmental Health Sciences ⓘ National Institutes of Health ⓘ National Toxicology Program ⓘ United States Environmental Protection Agency ⓘ surface form: U.S. Environmental Protection Agency Food and Drug Administration ⓘ surface form: U.S. Food and Drug Administration
country	United States of America ⓘ surface form: United States
dataType	bioactivity profiles ⓘ chemical structure information ⓘ dose–response data ⓘ high-throughput screening data ⓘ
field	computational toxicology ⓘ environmental health ⓘ toxicology ⓘ
focus	human-relevant toxicity endpoints ⓘ mechanistic understanding of toxicity pathways ⓘ screening large numbers of environmental chemicals ⓘ
goal	improve prediction of chemical toxicity in humans ⓘ reduce reliance on traditional animal testing ⓘ
hasOutput	computational toxicity prediction tools ⓘ publicly available toxicity datasets ⓘ scientific publications on alternative toxicology methods ⓘ
method	bioinformatics analysis ⓘ computational modeling ⓘ high-throughput screening ⓘ in vitro assays ⓘ
relatedTo	21st century toxicology paradigm ⓘ adverse outcome pathways ⓘ risk assessment modernization ⓘ
shortName	Toxicology in the 21st Century program self-linksurface differs ⓘ surface form: Tox21
uses	cell-based assays ⓘ computational prediction models ⓘ molecular target assays ⓘ robotic assay platforms ⓘ

Referenced by (2)

Full triples — surface form annotated when it differs from this entity's canonical label.

National Center for Advancing Translational Sciences → operates → Toxicology in the 21st Century program ⓘ

Toxicology in the 21st Century program → shortName → Toxicology in the 21st Century program self-linksurface differs ⓘ

this entity surface form: Tox21