trapped neutrophil syndrome
E938598
canine genetic disease
congenital neutrophil disorder
inherited immune disorder
primary immunodeficiency
Trapped neutrophil syndrome is an inherited immune disorder in dogs, particularly Border Collies, in which white blood cells fail to mature and function properly, leading to recurrent infections and early death.
All labels observed (1)
| Label | Occurrences |
|---|---|
| trapped neutrophil syndrome canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11631966 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: trapped neutrophil syndrome Context triple: [Border Collie, geneticTestRecommendedFor, trapped neutrophil syndrome]
-
A.
PNH
PNH is the IATA airport code for Phnom Penh International Airport, the main international gateway to Cambodia’s capital city.
-
B.
microscopic polyangiitis
Microscopic polyangiitis is a rare autoimmune small-vessel vasculitis that causes inflammation and damage in organs such as the kidneys, lungs, and nerves, often associated with anti-neutrophil cytoplasmic antibodies (ANCA).
-
C.
PR3-ANCA
PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
-
D.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
-
E.
erythema nodosum
Erythema nodosum is an inflammatory condition characterized by tender red nodules, usually on the shins, often associated with systemic diseases such as infections, autoimmune disorders, and inflammatory bowel disease.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: trapped neutrophil syndrome Target entity description: Trapped neutrophil syndrome is an inherited immune disorder in dogs, particularly Border Collies, in which white blood cells fail to mature and function properly, leading to recurrent infections and early death.
-
A.
PNH
PNH is the IATA airport code for Phnom Penh International Airport, the main international gateway to Cambodia’s capital city.
-
B.
microscopic polyangiitis
Microscopic polyangiitis is a rare autoimmune small-vessel vasculitis that causes inflammation and damage in organs such as the kidneys, lungs, and nerves, often associated with anti-neutrophil cytoplasmic antibodies (ANCA).
-
C.
PR3-ANCA
PR3-ANCA is an autoantibody directed against proteinase 3 that is strongly associated with granulomatosis with polyangiitis (formerly Wegener's granulomatosis) and used as a key diagnostic marker for this vasculitic disease.
-
D.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
-
E.
erythema nodosum
Erythema nodosum is an inflammatory condition characterized by tender red nodules, usually on the shins, often associated with systemic diseases such as infections, autoimmune disorders, and inflammatory bowel disease.
- F. None of above. chosen
Statements (37)
| Predicate | Object |
|---|---|
| instanceOf |
canine genetic disease
ⓘ
congenital neutrophil disorder ⓘ inherited immune disorder ⓘ primary immunodeficiency ⓘ |
| affectsCellType | neutrophil ⓘ |
| affectsSpecies | dog ⓘ |
| alsoKnownAs | TNS NERFINISHED ⓘ |
| belongsToCategory |
hereditary neutrophil disorder
ⓘ
veterinary hematologic disease ⓘ veterinary immunologic disease ⓘ |
| commonlyAffectsBreed | Border Collie NERFINISHED ⓘ |
| diagnosedBy |
DNA test
ⓘ
bone marrow examination ⓘ complete blood count ⓘ |
| diseaseLocation | bone marrow ⓘ |
| hasCause | genetic mutation ⓘ |
| hasOnset | early puppyhood ⓘ |
| hasSymptom |
diarrhea
ⓘ
failure to thrive ⓘ fever ⓘ lethargy ⓘ poor growth ⓘ recurrent infections ⓘ respiratory infections ⓘ |
| inheritancePattern | autosomal recessive ⓘ |
| laboratoryFinding |
abnormal neutrophil morphology
ⓘ
persistent neutropenia ⓘ |
| management |
antibiotic therapy for infections
ⓘ
supportive care ⓘ |
| pathophysiology |
defective neutrophil release from bone marrow
ⓘ
failure of neutrophil maturation ⓘ neutropenia ⓘ |
| prevention | genetic screening of breeding dogs ⓘ |
| prognosis | poor ⓘ |
| transmission | both parents must be carriers ⓘ |
| typicalOutcome |
early death
ⓘ
shortened lifespan ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: trapped neutrophil syndrome Description of subject: Trapped neutrophil syndrome is an inherited immune disorder in dogs, particularly Border Collies, in which white blood cells fail to mature and function properly, leading to recurrent infections and early death.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.