trapped neutrophil syndrome
E938598
canine genetic disease
congenital neutrophil disorder
inherited immune disorder
primary immunodeficiency
Trapped neutrophil syndrome is an inherited immune disorder in dogs, particularly Border Collies, in which white blood cells fail to mature and function properly, leading to recurrent infections and early death.
Statements (37)
| Predicate | Object |
|---|---|
| instanceOf |
canine genetic disease
ⓘ
congenital neutrophil disorder ⓘ inherited immune disorder ⓘ primary immunodeficiency ⓘ |
| affectsCellType | neutrophil ⓘ |
| affectsSpecies | dog ⓘ |
| alsoKnownAs | TNS NERFINISHED ⓘ |
| belongsToCategory |
hereditary neutrophil disorder
ⓘ
veterinary hematologic disease ⓘ veterinary immunologic disease ⓘ |
| commonlyAffectsBreed | Border Collie NERFINISHED ⓘ |
| diagnosedBy |
DNA test
ⓘ
bone marrow examination ⓘ complete blood count ⓘ |
| diseaseLocation | bone marrow ⓘ |
| hasCause | genetic mutation ⓘ |
| hasOnset | early puppyhood ⓘ |
| hasSymptom |
diarrhea
ⓘ
failure to thrive ⓘ fever ⓘ lethargy ⓘ poor growth ⓘ recurrent infections ⓘ respiratory infections ⓘ |
| inheritancePattern | autosomal recessive ⓘ |
| laboratoryFinding |
abnormal neutrophil morphology
ⓘ
persistent neutropenia ⓘ |
| management |
antibiotic therapy for infections
ⓘ
supportive care ⓘ |
| pathophysiology |
defective neutrophil release from bone marrow
ⓘ
failure of neutrophil maturation ⓘ neutropenia ⓘ |
| prevention | genetic screening of breeding dogs ⓘ |
| prognosis | poor ⓘ |
| transmission | both parents must be carriers ⓘ |
| typicalOutcome |
early death
ⓘ
shortened lifespan ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.