tetanus
E928075
Tetanus is a serious, often life-threatening infectious disease of the nervous system caused by the toxin of the bacterium Clostridium tetani, leading to painful muscle stiffness and spasms.
Statements (59)
| Predicate | Object |
|---|---|
| instanceOf |
infectious disease
ⓘ
toxin-mediated disease ⓘ vaccine-preventable disease ⓘ |
| affectsSystem |
musculoskeletal system
ⓘ
nervous system ⓘ |
| causativeAgent | Clostridium tetani NERFINISHED ⓘ |
| hasCause | tetanospasmin toxin ⓘ |
| hasComplication |
aspiration pneumonia
ⓘ
autonomic dysfunction ⓘ bone fractures from severe spasms ⓘ death ⓘ respiratory failure ⓘ |
| hasForm |
cephalic tetanus
ⓘ
generalized tetanus ⓘ localized tetanus ⓘ neonatal tetanus ⓘ |
| hasHighMortalityWithoutTreatment | true ⓘ |
| hasIncubationPeriod |
3 to 21 days
ⓘ
commonly about 8 days ⓘ |
| hasPathophysiology |
disinhibition of motor neurons causes sustained muscle contraction
ⓘ
toxin blocks inhibitory neurotransmitter release ⓘ |
| hasRiskFactor |
burns
ⓘ
contaminated wounds ⓘ crush injuries ⓘ diabetes-related foot ulcers ⓘ inadequate vaccination ⓘ injecting drug use ⓘ necrotic tissue ⓘ puncture wounds ⓘ unsterile obstetric or surgical procedures ⓘ |
| hasSymptom |
dysphagia
ⓘ
fever ⓘ hypertension ⓘ lockjaw ⓘ muscle stiffness ⓘ opisthotonos ⓘ painful muscle spasms ⓘ rigid abdominal muscles ⓘ sweating ⓘ tachycardia ⓘ trismus ⓘ |
| isMoreCommonIn | low- and middle-income countries ⓘ |
| isNotEradicableByHumanToHumanControl | true ⓘ |
| isTargetOf | global vaccination programs ⓘ |
| nonTransmissibleBetweenHumans | true ⓘ |
| notifiableDiseaseInManyCountries | true ⓘ |
| occursWorldwide | true ⓘ |
| preventedBy |
DTaP vaccine
NERFINISHED
ⓘ
Td vaccine NERFINISHED ⓘ Tdap vaccine NERFINISHED ⓘ proper wound care ⓘ tetanus toxoid vaccine ⓘ |
| transmission |
contamination of wounds with C. tetani spores
ⓘ
environmental exposure to soil containing C. tetani spores ⓘ |
| treatedBy |
benzodiazepines
ⓘ
human tetanus immune globulin ⓘ mechanical ventilation ⓘ metronidazole ⓘ neuromuscular blocking agents ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.