paclitaxel
E906737
Paclitaxel is a chemotherapy drug that stabilizes microtubules to inhibit cell division and is widely used to treat various cancers, including breast, ovarian, and lung cancers.
All labels observed (1)
| Label | Occurrences |
|---|---|
| paclitaxel canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11145523 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: paclitaxel Context triple: [pertuzumab, oftenUsedWith, paclitaxel]
-
A.
docetaxel
Docetaxel is a chemotherapy drug in the taxane class used to treat various cancers, including breast, lung, prostate, and gastric cancers, by inhibiting cell division.
-
B.
Alimta
Alimta is a chemotherapy drug (pemetrexed) primarily used to treat malignant pleural mesothelioma and non-small cell lung cancer.
-
C.
Taxotere
Taxotere is a chemotherapy medication containing docetaxel, commonly used to treat various cancers such as breast, lung, prostate, and gastric cancers.
-
D.
irinotecan
Irinotecan is a chemotherapy drug, specifically a topoisomerase I inhibitor, commonly used to treat colorectal and other cancers.
-
E.
lapatinib
Lapatinib is an oral small-molecule tyrosine kinase inhibitor used primarily to treat HER2-positive breast cancer.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: paclitaxel Target entity description: Paclitaxel is a chemotherapy drug that stabilizes microtubules to inhibit cell division and is widely used to treat various cancers, including breast, ovarian, and lung cancers.
-
A.
docetaxel
Docetaxel is a chemotherapy drug in the taxane class used to treat various cancers, including breast, lung, prostate, and gastric cancers, by inhibiting cell division.
-
B.
Alimta
Alimta is a chemotherapy drug (pemetrexed) primarily used to treat malignant pleural mesothelioma and non-small cell lung cancer.
-
C.
Taxotere
Taxotere is a chemotherapy medication containing docetaxel, commonly used to treat various cancers such as breast, lung, prostate, and gastric cancers.
-
D.
irinotecan
Irinotecan is a chemotherapy drug, specifically a topoisomerase I inhibitor, commonly used to treat colorectal and other cancers.
-
E.
lapatinib
Lapatinib is an oral small-molecule tyrosine kinase inhibitor used primarily to treat HER2-positive breast cancer.
- F. None of above. chosen
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
antineoplastic agent
ⓘ
chemotherapy drug ⓘ microtubule-stabilizing agent ⓘ mitotic inhibitor ⓘ taxane ⓘ |
| belongsToPharmacologicClass |
antimicrotubule agents
ⓘ
plant alkaloids ⓘ |
| bindsTo | serum albumin ⓘ |
| derivedFrom |
Taxus brevifolia
ⓘ
yew trees ⓘ |
| discoveredIn | 1960s ⓘ |
| FDAApprovalYear | 1992 ⓘ |
| firstApprovedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
| hasAdverseEffect |
alopecia
ⓘ
arthralgia ⓘ hypersensitivity reactions ⓘ mucositis ⓘ myalgia ⓘ myelosuppression ⓘ nausea ⓘ neutropenia ⓘ peripheral neuropathy ⓘ vomiting ⓘ |
| hasATCCode | L01CD01 ⓘ |
| hasCASNumber | 33069-62-4 ⓘ |
| hasChEBIID | CHEBI:45863 ⓘ |
| hasDrugBankID | DB01229 ⓘ |
| hasEliminationHalfLife | approximately 5 to 24 hours ⓘ |
| hasFormulation |
albumin-bound nanoparticle formulation
ⓘ
conventional solvent-based formulation with Cremophor EL ⓘ |
| hasIUPACName | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-11-acetoxy-12-(benzoyloxy)-1,2a,6,9,12,12b-hexahydroxy-4,6-dimethyl-4a,8,13,13-tetramethyl-5-oxo-5H-4,11-methanobenzo[10]annulene-3,7-dione 4,10-diacetate NERFINISHED ⓘ |
| hasMechanismOfAction |
arrests cells in G2/M phase of the cell cycle
ⓘ
inhibits microtubule depolymerization ⓘ stabilizes microtubules ⓘ |
| hasMolarMass | 853.91 g/mol ⓘ |
| hasMolecularFormula | C47H51NO14 ⓘ |
| hasPregnancyCategory | D (US, historical) ⓘ |
| hasProteinBinding | 89–98% ⓘ |
| hasPubChemCID | 36314 ⓘ |
| hasRouteOfAdministration |
intraperitoneal
ⓘ
intravenous ⓘ |
| hasTradeName |
Abraxane
NERFINISHED
ⓘ
Onxol NERFINISHED ⓘ Taxol NERFINISHED ⓘ |
| hasUNII | P3G3EZJ37E ⓘ |
| isContraindicatedIn |
severe hypersensitivity to paclitaxel
ⓘ
severe neutropenia ⓘ |
| metabolizedBy |
CYP2C8
NERFINISHED
ⓘ
CYP3A4 NERFINISHED ⓘ |
| requiresPremedicationWith |
H1 antihistamines
ⓘ
H2 antagonists ⓘ corticosteroids ⓘ |
| targets | β-tubulin ⓘ |
| usedForTreatmentOf |
Kaposi sarcoma
NERFINISHED
ⓘ
bladder cancer ⓘ breast cancer ⓘ esophageal cancer ⓘ gastric cancer ⓘ head and neck cancer ⓘ non-small cell lung cancer ⓘ ovarian cancer ⓘ pancreatic cancer ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: paclitaxel Description of subject: Paclitaxel is a chemotherapy drug that stabilizes microtubules to inhibit cell division and is widely used to treat various cancers, including breast, ovarian, and lung cancers.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.