paclitaxel
E906737
Paclitaxel is a chemotherapy drug that stabilizes microtubules to inhibit cell division and is widely used to treat various cancers, including breast, ovarian, and lung cancers.
Statements (62)
| Predicate | Object |
|---|---|
| instanceOf |
antineoplastic agent
ⓘ
chemotherapy drug ⓘ microtubule-stabilizing agent ⓘ mitotic inhibitor ⓘ taxane ⓘ |
| belongsToPharmacologicClass |
antimicrotubule agents
ⓘ
plant alkaloids ⓘ |
| bindsTo | serum albumin ⓘ |
| derivedFrom |
Taxus brevifolia
ⓘ
yew trees ⓘ |
| discoveredIn | 1960s ⓘ |
| FDAApprovalYear | 1992 ⓘ |
| firstApprovedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
| hasAdverseEffect |
alopecia
ⓘ
arthralgia ⓘ hypersensitivity reactions ⓘ mucositis ⓘ myalgia ⓘ myelosuppression ⓘ nausea ⓘ neutropenia ⓘ peripheral neuropathy ⓘ vomiting ⓘ |
| hasATCCode | L01CD01 ⓘ |
| hasCASNumber | 33069-62-4 ⓘ |
| hasChEBIID | CHEBI:45863 ⓘ |
| hasDrugBankID | DB01229 ⓘ |
| hasEliminationHalfLife | approximately 5 to 24 hours ⓘ |
| hasFormulation |
albumin-bound nanoparticle formulation
ⓘ
conventional solvent-based formulation with Cremophor EL ⓘ |
| hasIUPACName | (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-11-acetoxy-12-(benzoyloxy)-1,2a,6,9,12,12b-hexahydroxy-4,6-dimethyl-4a,8,13,13-tetramethyl-5-oxo-5H-4,11-methanobenzo[10]annulene-3,7-dione 4,10-diacetate NERFINISHED ⓘ |
| hasMechanismOfAction |
arrests cells in G2/M phase of the cell cycle
ⓘ
inhibits microtubule depolymerization ⓘ stabilizes microtubules ⓘ |
| hasMolarMass | 853.91 g/mol ⓘ |
| hasMolecularFormula | C47H51NO14 ⓘ |
| hasPregnancyCategory | D (US, historical) ⓘ |
| hasProteinBinding | 89–98% ⓘ |
| hasPubChemCID | 36314 ⓘ |
| hasRouteOfAdministration |
intraperitoneal
ⓘ
intravenous ⓘ |
| hasTradeName |
Abraxane
NERFINISHED
ⓘ
Onxol NERFINISHED ⓘ Taxol NERFINISHED ⓘ |
| hasUNII | P3G3EZJ37E ⓘ |
| isContraindicatedIn |
severe hypersensitivity to paclitaxel
ⓘ
severe neutropenia ⓘ |
| metabolizedBy |
CYP2C8
NERFINISHED
ⓘ
CYP3A4 NERFINISHED ⓘ |
| requiresPremedicationWith |
H1 antihistamines
ⓘ
H2 antagonists ⓘ corticosteroids ⓘ |
| targets | β-tubulin ⓘ |
| usedForTreatmentOf |
Kaposi sarcoma
NERFINISHED
ⓘ
bladder cancer ⓘ breast cancer ⓘ esophageal cancer ⓘ gastric cancer ⓘ head and neck cancer ⓘ non-small cell lung cancer ⓘ ovarian cancer ⓘ pancreatic cancer ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.