Monod–Wyman–Changeux model
E906381
The Monod–Wyman–Changeux model is a foundational allosteric theory in biochemistry that explains how proteins can exist in multiple conformational states whose equilibrium is shifted by ligand binding.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Monod–Wyman–Changeux model canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11120904 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Monod–Wyman–Changeux model Context triple: [Jacques Monod, knownFor, Monod–Wyman–Changeux model]
-
A.
Hill equation
The Hill equation is a mathematical expression used in biochemistry and physiology to describe how the binding of ligands to macromolecules or the response to a drug depends on ligand concentration, often capturing cooperative binding behavior.
-
B.
Hodgkin–Huxley model
The Hodgkin–Huxley model is a mathematical description of how action potentials in neurons are initiated and propagated through voltage-gated ion channels in the cell membrane.
-
C.
Goldman–Hodgkin–Katz equation
The Goldman–Hodgkin–Katz equation is a biophysical formula that calculates a cell’s membrane potential by accounting for the relative permeabilities and concentrations of multiple ion species across the membrane.
-
D.
Tomonaga model
The Tomonaga model is an early theoretical framework in condensed matter physics that describes interacting electrons in one dimension and laid the groundwork for what became known as Luttinger liquid theory.
-
E.
Bohr effect
The Bohr effect is a physiological phenomenon in which increases in carbon dioxide concentration and acidity reduce hemoglobin’s affinity for oxygen, thereby facilitating oxygen release to tissues.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Monod–Wyman–Changeux model Target entity description: The Monod–Wyman–Changeux model is a foundational allosteric theory in biochemistry that explains how proteins can exist in multiple conformational states whose equilibrium is shifted by ligand binding.
-
A.
Hill equation
The Hill equation is a mathematical expression used in biochemistry and physiology to describe how the binding of ligands to macromolecules or the response to a drug depends on ligand concentration, often capturing cooperative binding behavior.
-
B.
Hodgkin–Huxley model
The Hodgkin–Huxley model is a mathematical description of how action potentials in neurons are initiated and propagated through voltage-gated ion channels in the cell membrane.
-
C.
Goldman–Hodgkin–Katz equation
The Goldman–Hodgkin–Katz equation is a biophysical formula that calculates a cell’s membrane potential by accounting for the relative permeabilities and concentrations of multiple ion species across the membrane.
-
D.
Tomonaga model
The Tomonaga model is an early theoretical framework in condensed matter physics that describes interacting electrons in one dimension and laid the groundwork for what became known as Luttinger liquid theory.
-
E.
Bohr effect
The Bohr effect is a physiological phenomenon in which increases in carbon dioxide concentration and acidity reduce hemoglobin’s affinity for oxygen, thereby facilitating oxygen release to tissues.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
allosteric model
ⓘ
biochemical theory ⓘ theoretical model of protein regulation ⓘ |
| alsoKnownAs |
MWC model
NERFINISHED
ⓘ
concerted model ⓘ |
| appliedTo |
allosteric enzymes
ⓘ
hemoglobin oxygen binding ⓘ membrane receptors ⓘ |
| assumes |
all subunits are in the same conformation at any given time
ⓘ
allosteric proteins are oligomeric ⓘ equilibrium between conformational states is shifted by ligand binding ⓘ proteins exist in multiple conformational states ⓘ subunits in an oligomer switch conformation in a concerted manner ⓘ symmetry of the oligomer is conserved during conformational transitions ⓘ |
| category |
cooperative binding models
ⓘ
protein allostery ⓘ |
| contrastedWith |
Koshland–Némethy–Filmer model
NERFINISHED
ⓘ
sequential model of allostery ⓘ |
| coreIdea |
allosteric effects arise from population shifts between states
ⓘ
ligand binding shifts conformational equilibrium ⓘ ligands preferentially bind one conformational state ⓘ |
| describes |
allosteric regulation
ⓘ
cooperative ligand binding ⓘ |
| explains |
allosteric transitions in multimeric proteins
ⓘ
positive cooperativity ⓘ sigmoidal binding curves ⓘ |
| field |
biochemistry
ⓘ
biophysics ⓘ molecular biology ⓘ |
| historicalImportance | first widely accepted quantitative theory of allostery ⓘ |
| includesConcept |
allosteric constant L
ⓘ
equilibrium between T and R states ⓘ ligand binding affinity differences between states ⓘ relaxed state ⓘ tense state ⓘ |
| influenced |
models of receptor activation
ⓘ
modern theories of allosteric regulation ⓘ |
| mathematicalFormulation | equations relating saturation to ligand concentration and allosteric constant ⓘ |
| namedAfter |
Jacques Monod
NERFINISHED
ⓘ
Jean-Pierre Changeux NERFINISHED ⓘ Jeffries Wyman NERFINISHED ⓘ |
| publicationYear | 1965 ⓘ |
| relatedTo |
Hill coefficient
NERFINISHED
ⓘ
allosteric constant ⓘ thermodynamic linkage theory ⓘ |
| usedFor |
fitting experimental binding data
ⓘ
interpreting cooperative binding curves ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Monod–Wyman–Changeux model Description of subject: The Monod–Wyman–Changeux model is a foundational allosteric theory in biochemistry that explains how proteins can exist in multiple conformational states whose equilibrium is shifted by ligand binding.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.