Monod–Wyman–Changeux model

E906381

allosteric model biochemical theory theoretical model of protein regulation

The Monod–Wyman–Changeux model is a foundational allosteric theory in biochemistry that explains how proteins can exist in multiple conformational states whose equilibrium is shifted by ligand binding.

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Statements (47)

Predicate	Object
instanceOf	allosteric model ⓘ biochemical theory ⓘ theoretical model of protein regulation ⓘ
alsoKnownAs	MWC model NERFINISHED ⓘ concerted model ⓘ
appliedTo	allosteric enzymes ⓘ hemoglobin oxygen binding ⓘ membrane receptors ⓘ
assumes	all subunits are in the same conformation at any given time ⓘ allosteric proteins are oligomeric ⓘ equilibrium between conformational states is shifted by ligand binding ⓘ proteins exist in multiple conformational states ⓘ subunits in an oligomer switch conformation in a concerted manner ⓘ symmetry of the oligomer is conserved during conformational transitions ⓘ
category	cooperative binding models ⓘ protein allostery ⓘ
contrastedWith	Koshland–Némethy–Filmer model NERFINISHED ⓘ sequential model of allostery ⓘ
coreIdea	allosteric effects arise from population shifts between states ⓘ ligand binding shifts conformational equilibrium ⓘ ligands preferentially bind one conformational state ⓘ
describes	allosteric regulation ⓘ cooperative ligand binding ⓘ
explains	allosteric transitions in multimeric proteins ⓘ positive cooperativity ⓘ sigmoidal binding curves ⓘ
field	biochemistry ⓘ biophysics ⓘ molecular biology ⓘ
historicalImportance	first widely accepted quantitative theory of allostery ⓘ
includesConcept	allosteric constant L ⓘ equilibrium between T and R states ⓘ ligand binding affinity differences between states ⓘ relaxed state ⓘ tense state ⓘ
influenced	models of receptor activation ⓘ modern theories of allosteric regulation ⓘ
mathematicalFormulation	equations relating saturation to ligand concentration and allosteric constant ⓘ
namedAfter	Jacques Monod NERFINISHED ⓘ Jean-Pierre Changeux NERFINISHED ⓘ Jeffries Wyman NERFINISHED ⓘ
publicationYear	1965 ⓘ
relatedTo	Hill coefficient NERFINISHED ⓘ allosteric constant ⓘ thermodynamic linkage theory ⓘ
usedFor	fitting experimental binding data ⓘ interpreting cooperative binding curves ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

Jacques Monod → knownFor → Monod–Wyman–Changeux model ⓘ