lac operon model
E906380
The lac operon model is a foundational concept in molecular biology that explains how bacteria regulate gene expression in response to the presence or absence of lactose.
All labels observed (1)
| Label | Occurrences |
|---|---|
| lac operon model canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11120901 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: lac operon model Context triple: [Jacques Monod, knownFor, lac operon model]
-
A.
one gene–one enzyme hypothesis
The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
-
B.
A Genetic Switch: Phage Lambda and Higher Organisms
"A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
-
C.
bacteriophage lambda
Bacteriophage lambda is a temperate virus that infects Escherichia coli and serves as a classic model system for studying gene regulation, lysogeny, and molecular genetics.
-
D.
Leloir pathway of galactose metabolism
The Leloir pathway of galactose metabolism is the primary biochemical route by which cells convert galactose into glucose-1-phosphate for entry into central energy and biosynthetic pathways.
-
E.
Molecular Biology of the Gene
Molecular Biology of the Gene is a landmark molecular biology textbook, co-authored by James Watson, that helped define and systematize modern understanding of DNA structure, gene function, and genetic regulation.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: lac operon model Target entity description: The lac operon model is a foundational concept in molecular biology that explains how bacteria regulate gene expression in response to the presence or absence of lactose.
-
A.
one gene–one enzyme hypothesis
The one gene–one enzyme hypothesis is a foundational concept in genetics proposing that each gene encodes a specific enzyme that affects a single step in a metabolic pathway.
-
B.
A Genetic Switch: Phage Lambda and Higher Organisms
"A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
-
C.
bacteriophage lambda
Bacteriophage lambda is a temperate virus that infects Escherichia coli and serves as a classic model system for studying gene regulation, lysogeny, and molecular genetics.
-
D.
Leloir pathway of galactose metabolism
The Leloir pathway of galactose metabolism is the primary biochemical route by which cells convert galactose into glucose-1-phosphate for entry into central energy and biosynthetic pathways.
-
E.
Molecular Biology of the Gene
Molecular Biology of the Gene is a landmark molecular biology textbook, co-authored by James Watson, that helped define and systematize modern understanding of DNA structure, gene function, and genetic regulation.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
concept in molecular biology
ⓘ
genetic regulatory model ⓘ |
| appliesTo |
Escherichia coli
NERFINISHED
ⓘ
other enteric bacteria ⓘ |
| associatedWithAward | 1965 Nobel Prize in Physiology or Medicine NERFINISHED ⓘ |
| basedOn | operon concept ⓘ |
| condition |
lactose absent leads to repression
ⓘ
lactose present and glucose absent leads to high expression ⓘ lactose present and glucose present leads to low expression ⓘ |
| demonstrates |
integration of multiple environmental signals
ⓘ
role of small molecules as inducers ⓘ transcriptional control in prokaryotes ⓘ |
| describes | regulation of lactose metabolism genes in bacteria ⓘ |
| explains |
catabolite repression
ⓘ
inducible gene expression ⓘ negative regulation of gene expression ⓘ positive regulation of gene expression ⓘ |
| field |
bacterial genetics
ⓘ
gene expression regulation ⓘ |
| historicallyProposedBy |
François Jacob
NERFINISHED
ⓘ
Jacques Monod NERFINISHED ⓘ |
| includesComponent |
CAP binding site
ⓘ
lacA gene ⓘ lacI gene ⓘ lacY gene NERFINISHED ⓘ lacZ gene ⓘ operator region ⓘ promoter region ⓘ |
| influenced |
development of operon theory
ⓘ
modern systems biology of gene networks ⓘ |
| involvesMolecule |
CAP protein
NERFINISHED
ⓘ
RNA polymerase ⓘ allolactose ⓘ cAMP ⓘ lac repressor protein ⓘ lactose ⓘ |
| locatedOn | E. coli chromosome NERFINISHED ⓘ |
| mechanism |
CAP–cAMP complex enhances RNA polymerase binding
ⓘ
inducer binds repressor to prevent operator binding ⓘ repressor binds operator to block transcription ⓘ |
| proposedInYear | 1961 ⓘ |
| regulates |
lactose permease production
ⓘ
thiogalactoside transacetylase production ⓘ β-galactosidase production ⓘ |
| shows |
coordinated regulation of multiple structural genes
ⓘ
polycistronic mRNA organization ⓘ |
| usedAs |
paradigm for gene regulation
ⓘ
teaching model in molecular biology ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: lac operon model Description of subject: The lac operon model is a foundational concept in molecular biology that explains how bacteria regulate gene expression in response to the presence or absence of lactose.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.