lac operon model
E906380
The lac operon model is a foundational concept in molecular biology that explains how bacteria regulate gene expression in response to the presence or absence of lactose.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
concept in molecular biology
ⓘ
genetic regulatory model ⓘ |
| appliesTo |
Escherichia coli
NERFINISHED
ⓘ
other enteric bacteria ⓘ |
| associatedWithAward | 1965 Nobel Prize in Physiology or Medicine NERFINISHED ⓘ |
| basedOn | operon concept ⓘ |
| condition |
lactose absent leads to repression
ⓘ
lactose present and glucose absent leads to high expression ⓘ lactose present and glucose present leads to low expression ⓘ |
| demonstrates |
integration of multiple environmental signals
ⓘ
role of small molecules as inducers ⓘ transcriptional control in prokaryotes ⓘ |
| describes | regulation of lactose metabolism genes in bacteria ⓘ |
| explains |
catabolite repression
ⓘ
inducible gene expression ⓘ negative regulation of gene expression ⓘ positive regulation of gene expression ⓘ |
| field |
bacterial genetics
ⓘ
gene expression regulation ⓘ |
| historicallyProposedBy |
François Jacob
NERFINISHED
ⓘ
Jacques Monod NERFINISHED ⓘ |
| includesComponent |
CAP binding site
ⓘ
lacA gene ⓘ lacI gene ⓘ lacY gene NERFINISHED ⓘ lacZ gene ⓘ operator region ⓘ promoter region ⓘ |
| influenced |
development of operon theory
ⓘ
modern systems biology of gene networks ⓘ |
| involvesMolecule |
CAP protein
NERFINISHED
ⓘ
RNA polymerase ⓘ allolactose ⓘ cAMP ⓘ lac repressor protein ⓘ lactose ⓘ |
| locatedOn | E. coli chromosome NERFINISHED ⓘ |
| mechanism |
CAP–cAMP complex enhances RNA polymerase binding
ⓘ
inducer binds repressor to prevent operator binding ⓘ repressor binds operator to block transcription ⓘ |
| proposedInYear | 1961 ⓘ |
| regulates |
lactose permease production
ⓘ
thiogalactoside transacetylase production ⓘ β-galactosidase production ⓘ |
| shows |
coordinated regulation of multiple structural genes
ⓘ
polycistronic mRNA organization ⓘ |
| usedAs |
paradigm for gene regulation
ⓘ
teaching model in molecular biology ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.