ERBB4
E903678
ERBB4 is a receptor tyrosine kinase of the ErbB/EGFR family involved in cell signaling pathways that regulate cell growth, differentiation, and development.
Statements (72)
| Predicate | Object |
|---|---|
| instanceOf |
ErbB receptor family member
ⓘ
human gene ⓘ protein ⓘ receptor tyrosine kinase ⓘ transmembrane receptor ⓘ |
| activatedBy |
betacellulin
NERFINISHED
ⓘ
heparin-binding EGF-like growth factor ⓘ neuregulin 1 NERFINISHED ⓘ neuregulin 2 NERFINISHED ⓘ neuregulin 3 NERFINISHED ⓘ neuregulin 4 NERFINISHED ⓘ |
| alsoKnownAs |
ERBB-4
NERFINISHED
ⓘ
HER4 NERFINISHED ⓘ proto-oncogene c-ERBB-4 ⓘ |
| associatedWithDisease |
bipolar disorder
ⓘ
breast cancer ⓘ medulloblastoma NERFINISHED ⓘ melanoma ⓘ non-small cell lung cancer ⓘ schizophrenia ⓘ |
| belongsToFamily |
EGFR family
NERFINISHED
ⓘ
ErbB receptor family NERFINISHED ⓘ |
| encodes | Receptor tyrosine-protein kinase erbB-4 NERFINISHED ⓘ |
| expressedInTissue |
brain
ⓘ
heart ⓘ kidney ⓘ lung ⓘ mammary gland ⓘ |
| formsHeterodimerWith |
EGFR
NERFINISHED
ⓘ
ERBB2 NERFINISHED ⓘ ERBB3 NERFINISHED ⓘ |
| hasAlternativeSplicing | multiple isoforms ⓘ |
| hasBiologicalProcess |
EGFR signaling pathway
ⓘ
ERBB signaling pathway ⓘ MAPK cascade ⓘ PI3K-Akt signaling pathway NERFINISHED ⓘ apoptotic process regulation ⓘ cell differentiation ⓘ cell growth ⓘ cell proliferation ⓘ cell survival ⓘ embryonic development ⓘ heart development ⓘ mammary gland development ⓘ nervous system development ⓘ signal transduction ⓘ |
| hasCellularComponent |
cell surface
ⓘ
integral component of plasma membrane ⓘ plasma membrane ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ |
| hasEnsemblGeneID | ENSG00000178568 ⓘ |
| hasEntrezGeneID | 2066 ⓘ |
| hasHGNCID | HGNC:3431 NERFINISHED ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
protein binding ⓘ protein tyrosine kinase activity ⓘ transmembrane receptor protein tyrosine kinase activity ⓘ |
| hasPostTranslationalModification |
proteolytic cleavage
ⓘ
tyrosine phosphorylation ⓘ |
| hasUniProtID | Q15303 ⓘ |
| locatedOnChromosome | chromosome 2 ⓘ |
| locatedOnChromosomeArm | 2q ⓘ |
| organism | Homo sapiens ⓘ |
| producesFragment | ERBB4 intracellular domain ⓘ |
| regulatesPathway |
cardiac muscle cell proliferation
ⓘ
neuronal migration ⓘ synapse development ⓘ |
| subcellularLocation |
cell membrane
ⓘ
cytoplasm ⓘ nucleus ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.