Taxotere
E902896
Taxotere is a chemotherapy medication containing docetaxel, commonly used to treat various cancers such as breast, lung, prostate, and gastric cancers.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Taxotere canonical | 1 |
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
chemotherapy medication ⓘ |
| contraindicatedIn |
patients with baseline neutrophil count below recommended threshold
ⓘ
severe hepatic impairment ⓘ |
| developedBy | Sanofi NERFINISHED ⓘ |
| dosageForm |
concentrate for solution for infusion
ⓘ
solution for infusion ⓘ |
| eliminationRoute | biliary excretion ⓘ |
| hasActiveIngredient | docetaxel NERFINISHED ⓘ |
| hasATCCode | L01CD02 ⓘ |
| hasDrugClass |
antineoplastic agent
ⓘ
mitotic inhibitor ⓘ taxane ⓘ |
| hasSeriousAdverseEffect |
cardiotoxicity
ⓘ
hepatotoxicity ⓘ interstitial lung disease ⓘ sepsis ⓘ severe neutropenia ⓘ |
| hasSideEffect |
alopecia
ⓘ
anemia ⓘ diarrhea ⓘ fatigue ⓘ febrile neutropenia ⓘ fluid retention ⓘ hypersensitivity reactions ⓘ mucositis ⓘ nausea ⓘ neutropenia ⓘ peripheral neuropathy ⓘ thrombocytopenia ⓘ vomiting ⓘ |
| indicationType | systemic cancer therapy ⓘ |
| mechanismOfAction |
inhibits mitosis in cancer cells
ⓘ
stabilizes microtubules and prevents depolymerization ⓘ |
| metabolism | hepatic ⓘ |
| metabolizedBy | CYP3A4 NERFINISHED ⓘ |
| oftenGivenWith |
cisplatin
ⓘ
cyclophosphamide NERFINISHED ⓘ doxorubicin ⓘ fluorouracil ⓘ prednisone ⓘ |
| pregnancyCategory | teratogenic risk (contraindicated in pregnancy) ⓘ |
| regulatoryStatus | prescription only ⓘ |
| requiresPremedicationWith | corticosteroids ⓘ |
| routeOfAdministration | intravenous ⓘ |
| targetsBiologicalProcess | microtubule dynamics ⓘ |
| usedForTreatmentOf |
breast cancer
ⓘ
gastric cancer ⓘ head and neck cancer ⓘ hormone-refractory metastatic prostate cancer ⓘ locally advanced breast cancer ⓘ metastatic breast cancer ⓘ non-small cell lung cancer ⓘ prostate cancer ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.