interleukin-4
E902892
Interleukin-4 is an immune signaling cytokine that promotes B cell proliferation, differentiation, and antibody class switching, particularly toward IgE production.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine
ⓘ
interleukin ⓘ signaling protein ⓘ |
| activates | STAT6 NERFINISHED ⓘ |
| actsOnCellType |
B cell
ⓘ
T helper cell ⓘ eosinophil ⓘ macrophage ⓘ mast cell ⓘ |
| associatedWithDisease |
IgE-mediated hypersensitivity
ⓘ
allergic asthma ⓘ allergic rhinitis ⓘ atopic dermatitis ⓘ food allergy ⓘ helminth infection response ⓘ |
| bindsTo |
IL-4 receptor type I
NERFINISHED
ⓘ
IL-4/IL-13 receptor type II ⓘ interleukin-4 receptor alpha chain ⓘ |
| chromosomalLocation | human chromosome 5q31.1 ⓘ |
| encodedBy | IL4 gene NERFINISHED ⓘ |
| foundInTaxon | Homo sapiens NERFINISHED ⓘ |
| hasAlternativeName |
B cell stimulatory factor 1
NERFINISHED
ⓘ
BSF-1 NERFINISHED ⓘ IL-4 NERFINISHED ⓘ |
| hasBiologicalProcess |
B cell differentiation
ⓘ
B cell proliferation ⓘ Th2 cell differentiation ⓘ allergic inflammatory response ⓘ alternative macrophage activation ⓘ antibody class switching to IgE ⓘ antibody class switching to IgG1 (in mice) ⓘ eosinophil recruitment ⓘ regulation of IgE production ⓘ regulation of Th1/Th2 balance ⓘ regulation of immune response ⓘ regulation of macrophage activation ⓘ |
| hasLength | 129 amino acids (mature human IL-4) ⓘ |
| hasMolecularFunction |
cytokine activity
ⓘ
growth factor activity ⓘ |
| hasStructure | four-helix bundle cytokine fold ⓘ |
| hasSubcellularLocation | extracellular space ⓘ |
| isSecretedProtein | true ⓘ |
| isTargetOfDrug |
dupilumab
NERFINISHED
ⓘ
pascolizumab NERFINISHED ⓘ pitrakinra NERFINISHED ⓘ |
| secretedByCellType |
NKT cell
ⓘ
Th2 cell ⓘ basophil ⓘ eosinophil ⓘ mast cell ⓘ |
| signalsThroughPathway | JAK-STAT signaling pathway NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.