BAFF

E902891

cytokine protein signaling molecule tumor necrosis factor family member

BAFF is a cytokine of the tumor necrosis factor (TNF) family that plays a crucial role in B cell survival, maturation, and homeostasis, and is implicated in various autoimmune diseases.

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Statements (50)

Predicate	Object
instanceOf	cytokine ⓘ protein ⓘ signaling molecule ⓘ tumor necrosis factor family member ⓘ
associatedWithDisease	B cell non-Hodgkin lymphoma NERFINISHED ⓘ Sjögren syndrome NERFINISHED ⓘ autoimmune thyroid disease ⓘ chronic graft-versus-host disease ⓘ chronic lymphocytic leukemia ⓘ mixed cryoglobulinemia ⓘ multiple sclerosis ⓘ rheumatoid arthritis ⓘ systemic lupus erythematosus NERFINISHED ⓘ systemic sclerosis ⓘ
bindsReceptor	BAFF-R NERFINISHED ⓘ BCMA NERFINISHED ⓘ TACI NERFINISHED ⓘ
encodedByGene	TNFSF13B gene NERFINISHED ⓘ
expressedBy	activated T cells ⓘ dendritic cells ⓘ monocytes ⓘ myeloid cells ⓘ neutrophils ⓘ stromal cells ⓘ
forms	higher-order oligomers ⓘ homotrimer ⓘ
hasAlternativeName	B lymphocyte stimulator NERFINISHED ⓘ B-cell activating factor NERFINISHED ⓘ BLyS NERFINISHED ⓘ TNFSF13B NERFINISHED ⓘ
hasMolecularForm	soluble cytokine ⓘ type II transmembrane protein precursor ⓘ
involvedInPathway	B cell receptor signaling modulation ⓘ NF-kappaB signaling pathway ⓘ
locatedIn	cell membrane ⓘ extracellular space ⓘ
memberOf	tumor necrosis factor ligand superfamily NERFINISHED ⓘ
overexpressionLeadsTo	autoantibody production ⓘ breakdown of B cell tolerance ⓘ
positivelyRegulates	B cell class switching ⓘ immunoglobulin production ⓘ
promotes	B cell proliferation ⓘ
regulates	B cell homeostasis ⓘ B cell maturation ⓘ B cell survival ⓘ
targetOfDrug	atacicept NERFINISHED ⓘ belimumab ⓘ blisibimod NERFINISHED ⓘ tabalumab NERFINISHED ⓘ
taxon	Homo sapiens NERFINISHED ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

B lymphocytes → regulatedBy → BAFF ⓘ