CD21
E902889
CD21 is a complement receptor (CR2) found on B cells and follicular dendritic cells that plays a key role in B cell activation and the immune response.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface receptor
ⓘ
complement receptor ⓘ immune system protein ⓘ membrane glycoprotein ⓘ |
| associatedWithDisease |
Epstein–Barr virus infection
ⓘ
chronic lymphocytic leukemia NERFINISHED ⓘ common variable immunodeficiency (some forms) ⓘ systemic lupus erythematosus NERFINISHED ⓘ |
| bindsMolecule |
C3d
ⓘ
C3dg ⓘ CD23 NERFINISHED ⓘ Epstein–Barr virus gp350/220 NERFINISHED ⓘ iC3b ⓘ |
| encodedByGene | CR2 gene NERFINISHED ⓘ |
| expressedOnCellType |
B cells
ⓘ
follicular dendritic cells ⓘ some T cell subsets (low levels) ⓘ some epithelial cells ⓘ |
| formsComplexWith |
CD19
NERFINISHED
ⓘ
CD225 ⓘ CD81 ⓘ |
| hasDomain |
extracellular domain with multiple SCR (short consensus repeat) domains
ⓘ
short cytoplasmic tail ⓘ single transmembrane domain ⓘ |
| hasFunction |
enhances B cell receptor signaling
ⓘ
facilitates immune memory formation ⓘ lowers B cell activation threshold ⓘ mediates complement-dependent B cell activation ⓘ participates in germinal center reactions ⓘ retains antigen on follicular dendritic cells ⓘ |
| hasSynonym |
C3d receptor
NERFINISHED
ⓘ
CR2 ⓘ complement receptor type 2 ⓘ |
| locatedOnChromosome | human chromosome 1q32 ⓘ |
| memberOf |
CD2 family
NERFINISHED
ⓘ
complement system receptors ⓘ |
| orthologFoundIn |
mouse
ⓘ
other mammals ⓘ rat ⓘ |
| participatesInPathway |
adaptive immune response
ⓘ
complement activation-dependent B cell signaling ⓘ germinal center formation ⓘ |
| partOf | B cell coreceptor complex NERFINISHED ⓘ |
| recognizedBy |
monoclonal antibody clone B-ly4
ⓘ
monoclonal antibody clone HB-5 NERFINISHED ⓘ |
| subcellularLocation | plasma membrane ⓘ |
| topology | type I transmembrane protein ⓘ |
| usedAsMarkerFor |
follicular dendritic cells
ⓘ
mature B cells ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.