Peyer’s patches
E902888
Peyer’s patches are organized lymphoid nodules in the small intestine that play a key role in gut-associated immune responses, particularly in generating antibody-producing B cells.
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
gut-associated lymphoid tissue
ⓘ
lymphoid nodule ⓘ secondary lymphoid organ ⓘ |
| antigenUptakeMediatedBy | M cells ⓘ |
| arrangedAlong | antimesenteric border of small intestine ⓘ |
| associatedWith |
mucosal homing of lymphocytes
ⓘ
secretory IgA production ⓘ |
| containsCellType |
B lymphocyte
ⓘ
M cell ⓘ T lymphocyte ⓘ dendritic cell ⓘ follicular dendritic cell ⓘ macrophage ⓘ |
| containsStructure |
B cell follicle
ⓘ
T cell–rich interfollicular area ⓘ germinal center ⓘ subepithelial dome ⓘ |
| coveredBy | follicle-associated epithelium ⓘ |
| developsPredominantly | in early life ⓘ |
| discoveredBy | Johann Conrad Peyer NERFINISHED ⓘ |
| drainsTo | mesenteric lymph nodes ⓘ |
| foundInLayer |
lamina propria
ⓘ
submucosa ⓘ |
| function |
defense against enteric pathogens
ⓘ
development of oral tolerance ⓘ generation of antibody-producing B cells ⓘ induction of IgA class switching ⓘ initiation of mucosal immune responses ⓘ sampling of luminal antigens ⓘ |
| hasEpitheliumType | specialized follicle-associated epithelium lacking typical villi ⓘ |
| hasHighEndothelialVenules | true ⓘ |
| locatedIn | small intestine ⓘ |
| locatedPrimarilyIn | ileum ⓘ |
| macroscopicAppearance | oval or elongated lymphoid aggregates ⓘ |
| moreNumerousIn | children ⓘ |
| namedAfter | Johann Conrad Peyer NERFINISHED ⓘ |
| numberVariesBetween | individuals GENERATED ⓘ |
| partOf |
gut-associated immune system
ⓘ
immune system ⓘ mucosa-associated lymphoid tissue ⓘ |
| roleInDisease |
entry site for some enteric pathogens
ⓘ
involved in pathogenesis of inflammatory bowel disease ⓘ |
| roleInVaccineResponse | target for oral vaccines GENERATED ⓘ |
| species |
present in humans
ⓘ
present in many mammals ⓘ |
| undergoes | age-related involution ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.