JAK-STAT signaling pathway
E902876
The JAK-STAT signaling pathway is a key intracellular cascade that transmits signals from cell-surface receptors to the nucleus to regulate gene expression involved in cell growth, differentiation, immune function, and survival.
All labels observed (1)
| Label | Occurrences |
|---|---|
| JAK-STAT signaling pathway canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074238 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: JAK-STAT signaling pathway Context triple: [HER2 receptor, activatesPathway, JAK-STAT signaling pathway]
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A.
Toll-like receptor signaling pathway
The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
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B.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
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C.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
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D.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
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E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: JAK-STAT signaling pathway Target entity description: The JAK-STAT signaling pathway is a key intracellular cascade that transmits signals from cell-surface receptors to the nucleus to regulate gene expression involved in cell growth, differentiation, immune function, and survival.
-
A.
Toll-like receptor signaling pathway
The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
-
B.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
C.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
-
D.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
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E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
Statements (58)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine signaling pathway
ⓘ
intracellular signaling cascade ⓘ signal transduction pathway ⓘ |
| abbreviationOf | Janus kinase-signal transducer and activator of transcription signaling pathway NERFINISHED ⓘ |
| activatedBy |
cytokines
ⓘ
growth factors ⓘ hormones ⓘ interferons ⓘ interleukins ⓘ |
| dysregulationAssociatedWith |
autoimmune diseases
ⓘ
immunodeficiency ⓘ leukemia ⓘ myeloproliferative neoplasms ⓘ solid tumors ⓘ |
| hasClinicalRelevanceIn |
inflammatory bowel disease
ⓘ
myelofibrosis NERFINISHED ⓘ polycythemia vera ⓘ psoriasis ⓘ rheumatoid arthritis ⓘ |
| hasComponent |
JAK1
NERFINISHED
ⓘ
JAK2 NERFINISHED ⓘ JAK3 NERFINISHED ⓘ STAT1 NERFINISHED ⓘ STAT2 NERFINISHED ⓘ STAT3 NERFINISHED ⓘ STAT4 NERFINISHED ⓘ STAT5A NERFINISHED ⓘ STAT5B NERFINISHED ⓘ STAT6 NERFINISHED ⓘ TYK2 NERFINISHED ⓘ |
| involves |
Janus kinases
NERFINISHED
ⓘ
signal transducers and activators of transcription ⓘ |
| isConservedIn |
invertebrates
ⓘ
vertebrates ⓘ |
| mechanismStep |
JAK activation by trans-phosphorylation
ⓘ
binding of STAT dimers to DNA response elements ⓘ dimerization of phosphorylated STATs ⓘ ligand-induced receptor dimerization ⓘ nuclear translocation of STAT dimers ⓘ phosphorylation of STAT proteins by JAKs ⓘ phosphorylation of receptor cytoplasmic tails ⓘ recruitment of STAT proteins to phosphorylated receptors ⓘ |
| occursAt |
cell membrane
ⓘ
cell nucleus ⓘ cytoplasm ⓘ |
| regulatedBy |
PIAS proteins
NERFINISHED
ⓘ
SOCS proteins NERFINISHED ⓘ protein tyrosine phosphatases ⓘ |
| regulates |
apoptosis
ⓘ
cell differentiation ⓘ cell proliferation ⓘ cell survival ⓘ gene expression ⓘ immune responses ⓘ inflammation ⓘ |
| startsWith | ligand binding to cell-surface receptor ⓘ |
| targetOf |
JAK inhibitors
ⓘ
STAT inhibitors ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: JAK-STAT signaling pathway Description of subject: The JAK-STAT signaling pathway is a key intracellular cascade that transmits signals from cell-surface receptors to the nucleus to regulate gene expression involved in cell growth, differentiation, immune function, and survival.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.