JAK-STAT signaling pathway

E902876

cytokine signaling pathway intracellular signaling cascade signal transduction pathway

The JAK-STAT signaling pathway is a key intracellular cascade that transmits signals from cell-surface receptors to the nucleus to regulate gene expression involved in cell growth, differentiation, immune function, and survival.

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Statements (58)

Predicate	Object
instanceOf	cytokine signaling pathway ⓘ intracellular signaling cascade ⓘ signal transduction pathway ⓘ
abbreviationOf	Janus kinase-signal transducer and activator of transcription signaling pathway NERFINISHED ⓘ
activatedBy	cytokines ⓘ growth factors ⓘ hormones ⓘ interferons ⓘ interleukins ⓘ
dysregulationAssociatedWith	autoimmune diseases ⓘ immunodeficiency ⓘ leukemia ⓘ myeloproliferative neoplasms ⓘ solid tumors ⓘ
hasClinicalRelevanceIn	inflammatory bowel disease ⓘ myelofibrosis NERFINISHED ⓘ polycythemia vera ⓘ psoriasis ⓘ rheumatoid arthritis ⓘ
hasComponent	JAK1 NERFINISHED ⓘ JAK2 NERFINISHED ⓘ JAK3 NERFINISHED ⓘ STAT1 NERFINISHED ⓘ STAT2 NERFINISHED ⓘ STAT3 NERFINISHED ⓘ STAT4 NERFINISHED ⓘ STAT5A NERFINISHED ⓘ STAT5B NERFINISHED ⓘ STAT6 NERFINISHED ⓘ TYK2 NERFINISHED ⓘ
involves	Janus kinases NERFINISHED ⓘ signal transducers and activators of transcription ⓘ
isConservedIn	invertebrates ⓘ vertebrates ⓘ
mechanismStep	JAK activation by trans-phosphorylation ⓘ binding of STAT dimers to DNA response elements ⓘ dimerization of phosphorylated STATs ⓘ ligand-induced receptor dimerization ⓘ nuclear translocation of STAT dimers ⓘ phosphorylation of STAT proteins by JAKs ⓘ phosphorylation of receptor cytoplasmic tails ⓘ recruitment of STAT proteins to phosphorylated receptors ⓘ
occursAt	cell membrane ⓘ cell nucleus ⓘ cytoplasm ⓘ
regulatedBy	PIAS proteins NERFINISHED ⓘ SOCS proteins NERFINISHED ⓘ protein tyrosine phosphatases ⓘ
regulates	apoptosis ⓘ cell differentiation ⓘ cell proliferation ⓘ cell survival ⓘ gene expression ⓘ immune responses ⓘ inflammation ⓘ
startsWith	ligand binding to cell-surface receptor ⓘ
targetOf	JAK inhibitors ⓘ STAT inhibitors ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

HER2 receptor → activatesPathway → JAK-STAT signaling pathway ⓘ