CD340
E902871
CD340 is an alternative name for the human epidermal growth factor receptor 2 (HER2), a cell surface receptor tyrosine kinase often overexpressed in certain aggressive breast and gastric cancers.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CD340 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074224 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CD340 Context triple: [HER2 receptor, hasAlternativeName, CD340]
-
A.
D40
D40 is the third-generation Nissan Navara mid-size pickup truck platform produced globally in the mid-2000s to 2010s.
-
B.
C40
C40 is a global network of major cities collaborating to address climate change and drive urban climate leadership.
-
C.
A40
A40 is a major French motorway, also known as the "Autoroute Blanche," that connects Mâcon to the Mont Blanc region through the Jura and Alps.
-
D.
A40
The A40 is a major road in England that runs from London through Oxford and on toward Wales, serving as an important east–west transport route.
-
E.
N40
N40 is a major national primary road in County Cork, Ireland, forming part of the city’s southern ring route and linking key radial routes around Cork.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CD340 Target entity description: CD340 is an alternative name for the human epidermal growth factor receptor 2 (HER2), a cell surface receptor tyrosine kinase often overexpressed in certain aggressive breast and gastric cancers.
-
A.
D40
D40 is the third-generation Nissan Navara mid-size pickup truck platform produced globally in the mid-2000s to 2010s.
-
B.
C40
C40 is a global network of major cities collaborating to address climate change and drive urban climate leadership.
-
C.
A40
A40 is a major French motorway, also known as the "Autoroute Blanche," that connects Mâcon to the Mont Blanc region through the Jura and Alps.
-
D.
A40
The A40 is a major road in England that runs from London through Oxford and on toward Wales, serving as an important east–west transport route.
-
E.
N40
N40 is a major national primary road in County Cork, Ireland, forming part of the city’s southern ring route and linking key radial routes around Cork.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface receptor
ⓘ
protein ⓘ receptor tyrosine kinase ⓘ |
| activatesPathway |
JAK-STAT signaling pathway
NERFINISHED
ⓘ
MAPK/ERK signaling pathway ⓘ PI3K-AKT signaling pathway NERFINISHED ⓘ |
| alternativeNameOf |
ERBB2
NERFINISHED
ⓘ
HER2 NERFINISHED ⓘ human epidermal growth factor receptor 2 NERFINISHED ⓘ |
| associatedWith |
aggressive breast cancer
ⓘ
metastasis ⓘ poor prognosis in breast cancer ⓘ poor prognosis in gastric cancer ⓘ tumor cell proliferation ⓘ tumor cell survival ⓘ |
| encodes | ERBB2 gene NERFINISHED ⓘ |
| formsComplexWith |
EGFR (ERBB1)
NERFINISHED
ⓘ
ERBB3 NERFINISHED ⓘ ERBB4 NERFINISHED ⓘ |
| hasBiologicalProcess |
cell differentiation
ⓘ
cell proliferation ⓘ epithelial cell development ⓘ signal transduction ⓘ |
| hasCDDesignation | CD340 ⓘ |
| hasCellularComponent |
cell surface
ⓘ
plasma membrane ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ |
| hasMolecularFunction |
protein tyrosine kinase activity
ⓘ
transmembrane receptor activity ⓘ |
| locatedOnChromosome | human chromosome 17q12 ⓘ |
| memberOf |
EGFR/ErbB family of receptor tyrosine kinases
NERFINISHED
ⓘ
ErbB receptor family NERFINISHED ⓘ |
| organism | Homo sapiens NERFINISHED ⓘ |
| overexpressedIn |
HER2-positive breast cancer
ⓘ
HER2-positive gastric cancer ⓘ |
| targetOf |
ado-trastuzumab emtansine
ⓘ
fam-trastuzumab deruxtecan NERFINISHED ⓘ lapatinib NERFINISHED ⓘ margetuximab NERFINISHED ⓘ neratinib NERFINISHED ⓘ pertuzumab ⓘ trastuzumab NERFINISHED ⓘ tucatinib NERFINISHED ⓘ |
| usedAsBiomarkerFor |
HER2-positive breast cancer
ⓘ
HER2-positive gastric cancer ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CD340 Description of subject: CD340 is an alternative name for the human epidermal growth factor receptor 2 (HER2), a cell surface receptor tyrosine kinase often overexpressed in certain aggressive breast and gastric cancers.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.