Hill–Robertson interference
E879131
Hill–Robertson interference is an evolutionary genetics concept describing how linkage between loci in finite populations reduces the efficiency of natural selection by causing beneficial and deleterious mutations to interfere with each other's fixation.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf | evolutionary genetics concept ⓘ |
| appliesTo |
asexual populations
ⓘ
diploid populations ⓘ haploid populations ⓘ sexual populations ⓘ |
| consequence |
reduced effective population size for selected loci
ⓘ
selection on one locus affects response at another linked locus ⓘ |
| context | linkage disequilibrium among selected sites ⓘ |
| describes |
interference among selected loci in finite populations
ⓘ
reduction in efficiency of natural selection due to linkage ⓘ |
| effect |
increased fixation probability of deleterious mutations
ⓘ
increased genetic draft ⓘ reduced adaptive evolution ⓘ reduced efficacy of natural selection ⓘ reduced fixation probability of beneficial mutations ⓘ |
| field |
evolutionary biology
ⓘ
population genetics ⓘ |
| involves |
beneficial mutations
ⓘ
deleterious mutations ⓘ finite population size ⓘ genetic drift ⓘ genetic linkage ⓘ linkage between loci ⓘ recombination ⓘ |
| mechanism |
competition among linked beneficial alleles
ⓘ
hitchhiking of deleterious alleles with beneficial alleles ⓘ stochastic associations between loci due to drift ⓘ |
| mitigatedBy |
increased recombination rate
ⓘ
recombination ⓘ |
| moreSevereIn |
regions of low recombination
ⓘ
small populations ⓘ tightly linked loci ⓘ |
| namedAfter |
Alan Robertson
NERFINISHED
ⓘ
William G. Hill NERFINISHED ⓘ |
| originallyDescribedIn | paper on linkage and selection in finite populations ⓘ |
| proposedBy |
Alan Robertson
NERFINISHED
ⓘ
William G. Hill NERFINISHED ⓘ |
| publicationYear | 1966 ⓘ |
| relatedTo |
Muller’s ratchet
NERFINISHED
ⓘ
background selection ⓘ clonal interference ⓘ genetic draft ⓘ selective sweeps ⓘ |
| supports | selection for higher recombination rates ⓘ |
| usedIn |
interpretation of patterns of genetic diversity
ⓘ
models of genome evolution ⓘ theory of evolution of recombination ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.