lamotrigine
E874311
Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy and bipolar disorder by stabilizing neuronal activity and reducing the frequency of seizures or mood episodes.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
anticonvulsant drug
ⓘ
antiepileptic drug ⓘ mood stabilizer ⓘ pharmaceutical drug ⓘ |
| administeredBy | oral route ⓘ |
| approvedForMedicalUseIn | 1994 in the United States ⓘ |
| availableAs |
chewable dispersible tablets
ⓘ
extended-release tablets ⓘ immediate-release tablets ⓘ |
| belongsToClass | phenyltriazines ⓘ |
| clearanceIncreasedBy | enzyme-inducing antiepileptic drugs ⓘ |
| commonAdverseEffect |
dizziness
ⓘ
headache ⓘ insomnia ⓘ nausea ⓘ rash ⓘ |
| contraindicatedIn | known hypersensitivity to lamotrigine ⓘ |
| developedBy | GlaxoSmithKline NERFINISHED ⓘ |
| discoveredIn | 1980s ⓘ |
| entersBreastMilk | true ⓘ |
| excretedBy | kidneys ⓘ |
| hasATCCode | N03AX09 ⓘ |
| hasBioavailability | approximately 98 percent ⓘ |
| hasCASNumber | 84057-84-1 ⓘ |
| hasChemicalFormula | C9H7Cl2N5O ⓘ |
| hasEliminationHalfLife | approximately 25 hours in adults ⓘ |
| hasIUPACName | 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine ⓘ |
| hasProteinBinding | approximately 55 percent ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| legalStatus | prescription-only medicine ⓘ |
| mechanismOfAction |
blocks voltage-gated sodium channels
ⓘ
inhibits glutamate release ⓘ reduces excitatory neurotransmission ⓘ stabilizes neuronal membranes ⓘ |
| metabolizedBy | hepatic glucuronidation ⓘ |
| passesPlacenta | true ⓘ |
| pregnancyCategory | varies by jurisdiction ⓘ |
| requires | slow dose titration ⓘ |
| riskIncreasedBy | coadministration with valproate ⓘ |
| seriousAdverseEffect |
Stevens–Johnson syndrome
NERFINISHED
ⓘ
drug reaction with eosinophilia and systemic symptoms ⓘ toxic epidermal necrolysis ⓘ |
| usedFor |
Lennox–Gastaut syndrome
NERFINISHED
ⓘ
bipolar disorder ⓘ epilepsy ⓘ focal seizures ⓘ generalized tonic-clonic seizures ⓘ maintenance treatment of bipolar I disorder ⓘ prevention of depressive episodes in bipolar disorder ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.