valproate
E874304
Valproate is an anticonvulsant and mood-stabilizing medication widely used to treat epilepsy, bipolar disorder, and to prevent migraine headaches.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
anticonvulsant
ⓘ
antiepileptic drug ⓘ mood stabilizer ⓘ pharmaceutical drug ⓘ |
| affectsMetabolismOf | lamotrigine NERFINISHED ⓘ |
| contraindicatedIn |
pregnancy
ⓘ
severe liver disease ⓘ |
| hasActiveForm |
sodium valproate
ⓘ
valproate semisodium NERFINISHED ⓘ valproic acid ⓘ |
| hasAdverseEffect |
alopecia
ⓘ
encephalopathy ⓘ hepatotoxicity ⓘ hyperammonemia ⓘ neural tube defects in fetus ⓘ pancreatitis ⓘ teratogenicity ⓘ thrombocytopenia ⓘ tremor ⓘ weight gain ⓘ |
| hasATCCode | N03AG01 ⓘ |
| hasBlackBoxWarningFor |
hepatotoxicity
ⓘ
pancreatitis ⓘ teratogenicity ⓘ |
| hasChemicalClass | short-chain fatty acid derivative ⓘ |
| hasDosageForm |
capsule
ⓘ
extended-release tablet ⓘ oral solution ⓘ tablet ⓘ |
| hasMechanismOfAction |
blocks voltage-gated sodium channels
ⓘ
increases brain GABA levels ⓘ inhibits histone deacetylases ⓘ modulates T-type calcium channels ⓘ |
| hasProteinBinding | high ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| isMetabolizedIn | liver ⓘ |
| isOnWHOModelListOfEssentialMedicines | true ⓘ |
| isPregnancyCategory |
D
ⓘ
X for migraine prophylaxis in pregnancy ⓘ |
| prevents | migraine headaches ⓘ |
| treats |
absence seizures
ⓘ
acute manic episodes ⓘ bipolar disorder ⓘ epilepsy ⓘ focal seizures ⓘ generalized tonic-clonic seizures ⓘ myoclonic seizures ⓘ |
| wasFirstApprovedIn | 1960s ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.