clobazam
E874303
Clobazam is a benzodiazepine medication primarily used as an anticonvulsant to treat certain types of epilepsy, including Lennox-Gastaut syndrome.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Clobazam | 0 |
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
GABAergic drug
ⓘ
anticonvulsant drug ⓘ anxiolytic drug ⓘ benzodiazepine ⓘ |
| bindsTo | GABAA receptor benzodiazepine site ⓘ |
| hasActiveMetabolite | N-desmethylclobazam ⓘ |
| hasATCCode | N03AE01 ⓘ |
| hasBlackBoxWarningUS | risks from concomitant use with opioids ⓘ |
| hasBrandName |
Frisium
NERFINISHED
ⓘ
Onfi NERFINISHED ⓘ |
| hasCASNumber | 22316-47-8 ⓘ |
| hasChemicalClass | 1,5-benzodiazepine ⓘ |
| hasCommonSideEffect |
aggression (especially in children)
ⓘ
ataxia ⓘ constipation ⓘ drooling ⓘ lethargy ⓘ sedation ⓘ somnolence ⓘ |
| hasContraindication |
history of benzodiazepine hypersensitivity
ⓘ
myasthenia gravis NERFINISHED ⓘ severe hepatic impairment ⓘ severe respiratory insufficiency ⓘ |
| hasDrugInteraction |
alcohol
ⓘ
opioids ⓘ other CNS depressants ⓘ strong CYP2C19 inhibitors ⓘ |
| hasEliminationHalfLife |
10–50 hours (parent drug)
ⓘ
36–42 hours (N-desmethylclobazam, approximate) ⓘ |
| hasIndication |
Lennox-Gastaut syndrome
NERFINISHED
ⓘ
adjunctive treatment of seizures ⓘ anxiety disorders (in some countries) ⓘ epilepsy ⓘ |
| hasIUPACName | 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-dione ⓘ |
| hasLegalStatusInUS | prescription only ⓘ |
| hasMechanismOfAction | positive allosteric modulator of GABAA receptor ⓘ |
| hasMolecularFormula | C16H13ClN2O2 ⓘ |
| hasPregnancyCategoryUS | C ⓘ |
| hasRisk |
abuse potential
ⓘ
suicidal ideation (class warning for antiepileptics) ⓘ tolerance with long-term use ⓘ |
| hasRouteOfAdministration |
oral
ⓘ
oral suspension ⓘ tablet ⓘ |
| hasSeriousSideEffect |
dependence
ⓘ
respiratory depression ⓘ withdrawal seizures ⓘ |
| isControlledSubstanceInUS | Schedule IV ⓘ |
| isExcretedBy |
fecal route
ⓘ
renal route ⓘ |
| isMetabolizedBy |
CYP2C19
NERFINISHED
ⓘ
CYP3A4 NERFINISHED ⓘ |
| isPrescriptionOnly | true ⓘ |
| wasApprovedBy | US Food and Drug Administration NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.