Melatonin
E873099
Melatonin is a hormone produced primarily by the pineal gland that helps regulate the body’s circadian rhythm and sleep-wake cycle.
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
chronobiotic agent
ⓘ
hormone ⓘ indoleamine ⓘ |
| actsOnReceptor |
MT1 receptor
NERFINISHED
ⓘ
MT2 receptor NERFINISHED ⓘ MT3 receptor (putative) NERFINISHED ⓘ |
| bindsTo | G protein–coupled receptors NERFINISHED ⓘ |
| chemicalFormula | C13H16N2O2 ⓘ |
| hasBiosyntheticEnzyme |
arylalkylamine N-acetyltransferase
ⓘ
hydroxyindole-O-methyltransferase ⓘ |
| hasFunction |
antioxidant activity
ⓘ
free radical scavenging ⓘ immunomodulatory effects ⓘ phase-shifting of circadian clock ⓘ sleep-promoting effect ⓘ |
| hasHalfLife | about 20–60 minutes in humans ⓘ |
| hasIUPACName | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide ⓘ |
| hasMainMetabolite | 6-sulfatoxymelatonin ⓘ |
| hasMolarMass | 232.278 g/mol ⓘ |
| hasPrecursor | serotonin NERFINISHED ⓘ |
| hasRouteOfAdministration |
oral
ⓘ
sublingual ⓘ transdermal ⓘ |
| hasSecretionPattern |
higher at night
ⓘ
lower during daytime ⓘ |
| influences |
core body temperature
ⓘ
hormone secretion rhythms ⓘ |
| isAvailableAs | dietary supplement ⓘ |
| isDerivedFrom | tryptophan ⓘ |
| isExcretedVia | urine ⓘ |
| isInhibitedBy | light exposure ⓘ |
| isMetabolizedPrimarilyIn | liver ⓘ |
| isProducedBy |
bone marrow cells
ⓘ
gastrointestinal tract ⓘ lymphocytes ⓘ pineal gland NERFINISHED ⓘ retina ⓘ |
| isRegulatedAs |
over-the-counter supplement in some countries
ⓘ
prescription drug in some countries ⓘ |
| isSecretedInto |
bloodstream
ⓘ
cerebrospinal fluid ⓘ |
| isStimulatedBy | darkness ⓘ |
| isSynthesizedVia | serotonin ⓘ |
| isUsedFor |
delayed sleep–wake phase disorder
ⓘ
insomnia management ⓘ jet lag ⓘ shift-work sleep disorder ⓘ |
| regulates |
circadian rhythm
ⓘ
sleep–wake cycle ⓘ |
| wasFirstIsolatedBy | Aaron B. Lerner NERFINISHED ⓘ |
| wasFirstIsolatedIn | 1958 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.