CD46
E854992
CD46 is a human cell-surface complement regulatory protein that also serves as an entry receptor for various pathogens, including certain adenoviruses and measles virus.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
cell-surface receptor
ⓘ
complement regulatory protein ⓘ glycoprotein ⓘ human protein ⓘ membrane protein ⓘ |
| actsAsReceptorFor |
Neisseria gonorrhoeae
NERFINISHED
ⓘ
Neisseria meningitidis NERFINISHED ⓘ Streptococcus pyogenes NERFINISHED ⓘ certain adenoviruses ⓘ human herpesvirus 6 NERFINISHED ⓘ measles virus ⓘ |
| associatedWith |
age-related macular degeneration
ⓘ
atypical hemolytic uremic syndrome NERFINISHED ⓘ pregnancy complications ⓘ |
| binds |
C3b
ⓘ
C4b ⓘ |
| chromosomalLocation | 1q32 ⓘ |
| discoveredAs | complement regulatory protein on human cells ⓘ |
| encodedBy | CD46 gene NERFINISHED ⓘ |
| expressedOn |
endothelial cells
ⓘ
epithelial cells ⓘ leukocytes ⓘ nucleated human cells ⓘ spermatozoa ⓘ |
| foundInSpecies | Homo sapiens ⓘ |
| hasAbbreviation | MCP NERFINISHED ⓘ |
| hasDomain | complement control protein domain ⓘ |
| hasFunction |
cofactor activity for factor I–mediated cleavage of C3b
ⓘ
cofactor activity for factor I–mediated cleavage of C4b ⓘ regulation of complement activation ⓘ |
| hasIsoform |
CD46 isoform with CYT-1 cytoplasmic tail
ⓘ
CD46 isoform with CYT-2 cytoplasmic tail ⓘ |
| hasPostTranslationalModification |
N-linked glycosylation
ⓘ
O-linked glycosylation ⓘ |
| hasRegion |
cytoplasmic tail
ⓘ
extracellular domain ⓘ transmembrane domain ⓘ |
| hasSynonym | membrane cofactor protein ⓘ |
| inhibits | complement cascade on host cells ⓘ |
| involvedIn |
T cell activation regulation
ⓘ
Th1 to Th2 switching ⓘ |
| locatedIn |
cell surface
ⓘ
plasma membrane ⓘ |
| memberOf | regulators of complement activation gene cluster ⓘ |
| participatesIn |
adaptive immune response modulation
ⓘ
innate immune response ⓘ |
| prevents | complement-mediated autologous cell lysis ⓘ |
| usedIn | oncolytic measles virus targeting strategies ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
human adenovirus serotype 26