St John’s wort
E850014
St John’s wort is a herbal antidepressant remedy derived from the plant Hypericum perforatum, widely used for mild to moderate depression but known for significant drug–drug interactions due to its induction of liver enzymes.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| St. John’s wort | 1 |
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
antidepressant
ⓘ
herbal medicinal product ⓘ phytotherapeutic agent ⓘ |
| adverseEffect |
dizziness
ⓘ
dry mouth ⓘ fatigue ⓘ gastrointestinal upset ⓘ photosensitivity ⓘ |
| causes | drug–drug interactions ⓘ |
| contraindicatedWith |
HIV protease inhibitors
ⓘ
cyclosporine NERFINISHED ⓘ irinotecan NERFINISHED ⓘ tacrolimus NERFINISHED ⓘ |
| derivedFrom | Hypericum perforatum NERFINISHED ⓘ |
| hasActiveConstituent |
flavonoids
ⓘ
hyperforin ⓘ hypericin ⓘ pseudohypericin ⓘ |
| hasCommonName | St John’s wort ⓘ |
| hasFormulation |
capsule
ⓘ
liquid extract ⓘ tablet ⓘ tea ⓘ |
| hasPharmacologicalEffect |
antidepressant effect
ⓘ
anxiolytic effect ⓘ |
| hasScientificName | Hypericum perforatum extract ⓘ |
| inducesEnzyme |
CYP2C19
NERFINISHED
ⓘ
CYP2C9 ⓘ CYP3A4 NERFINISHED ⓘ |
| inducesTransporter | P-glycoprotein NERFINISHED ⓘ |
| interactionMechanism |
enzyme induction in liver
ⓘ
increased drug metabolism ⓘ |
| mayReducePlasmaConcentrationOf |
HIV non-nucleoside reverse transcriptase inhibitors
ⓘ
HIV protease inhibitors ⓘ certain anticancer drugs ⓘ certain immunosuppressants ⓘ certain statins ⓘ cyclosporine NERFINISHED ⓘ oral contraceptives ⓘ warfarin ⓘ |
| mechanismOfAction |
inhibition of dopamine reuptake
ⓘ
inhibition of norepinephrine reuptake ⓘ inhibition of serotonin reuptake ⓘ modulation of GABA receptors ⓘ modulation of glutamate receptors ⓘ |
| regulatoryStatus | over-the-counter herbal medicine in many countries ⓘ |
| requires | medical supervision when combined with other medications ⓘ |
| risk |
reduced anticoagulant effect of warfarin
ⓘ
serotonin syndrome when combined with SSRIs ⓘ serotonin syndrome when combined with other serotonergic drugs ⓘ transplant rejection when combined with cyclosporine ⓘ unplanned pregnancy when combined with oral contraceptives ⓘ |
| standardizedTo |
hyperforin content
ⓘ
hypericin content ⓘ |
| typicalDoseRange | 300–900 mg per day of standardized extract ⓘ |
| usedFor |
mild depression
ⓘ
moderate depression ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.