NADPH
E850008
NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
coenzyme
ⓘ
reduced nicotinamide adenine dinucleotide phosphate ⓘ |
| chemicalFormula | C21H30N7O17P3 ⓘ |
| differsFrom | NADH by an extra phosphate group on the ribose of the adenosine moiety ⓘ |
| donates |
electrons
ⓘ
hydride ion ⓘ |
| hasCharge | -3 ⓘ |
| hasComponent |
adenine
ⓘ
nicotinamide ⓘ phosphate group ⓘ pyrophosphate bridge ⓘ ribose ⓘ |
| hasRedoxState | reduced GENERATED ⓘ |
| hasRole |
antioxidant system cofactor
ⓘ
biosynthetic cofactor ⓘ detoxification cofactor ⓘ reducing equivalent donor ⓘ |
| isChemicallySimilarTo | NADH NERFINISHED ⓘ |
| isCofactorFor |
HMG-CoA reductase
NERFINISHED
ⓘ
NADPH oxidase NERFINISHED ⓘ cytochrome P450 reductase NERFINISHED ⓘ fatty acid synthase NERFINISHED ⓘ glutathione reductase ⓘ nitric oxide synthase NERFINISHED ⓘ thioredoxin reductase NERFINISHED ⓘ |
| isConjugateWith | NADP+ ⓘ |
| isMoreAbundantIn | cytosol ⓘ |
| isProducedBy |
NADP+-dependent isocitrate dehydrogenase
ⓘ
malic enzyme reaction ⓘ oxidative branch of pentose phosphate pathway ⓘ pentose phosphate pathway ⓘ photosystem I ⓘ |
| isRequiredFor |
cholesterol synthesis
ⓘ
fatty acid chain elongation ⓘ maintenance of reduced glutathione ⓘ reactive oxygen species generation in immune cells ⓘ regeneration of ascorbate ⓘ |
| participatesIn |
anabolic metabolism
ⓘ
antioxidant defense ⓘ cholesterol biosynthesis ⓘ cytochrome P450–dependent reactions ⓘ deoxyribonucleotide synthesis ⓘ fatty acid synthesis ⓘ glutathione reduction ⓘ nitric oxide synthesis ⓘ nucleotide biosynthesis ⓘ photosynthetic carbon fixation ⓘ respiratory burst in phagocytes ⓘ steroid hormone biosynthesis ⓘ thioredoxin reduction ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.