probenecid
E850001
Probenecid is a uricosuric medication primarily used to treat gout and hyperuricemia and to modify the renal excretion of various drugs.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
gout medication
ⓘ
organic acid ⓘ pharmaceutical drug ⓘ small molecule ⓘ uricosuric agent ⓘ |
| actsOnTarget |
OAT1 transporter
ⓘ
OAT3 transporter ⓘ URAT1 transporter ⓘ |
| hasATCCode | M04AB01 ⓘ |
| hasBioavailability | high oral bioavailability ⓘ |
| hasCASNumber | 57-66-9 ⓘ |
| hasChemicalFormula | C13H19NO4S ⓘ |
| hasDrugInteractionWith |
NSAIDs
NERFINISHED
ⓘ
aspirin NERFINISHED ⓘ methotrexate ⓘ salicylates ⓘ |
| hasEliminationHalfLife | approximately 4 to 12 hours ⓘ |
| hasIUPACName | 4-[(dipropylsulfamoyl)methyl]benzoic acid ⓘ |
| hasMechanismOfAction |
inhibits organic anion transporters in renal proximal tubules
ⓘ
inhibits renal tubular reabsorption of uric acid ⓘ |
| hasMolarMass | 285.36 g/mol ⓘ |
| hasPregnancyCategory | varies by jurisdiction ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasTherapeuticUse |
adjunct to antibiotic therapy
ⓘ
prevention of gouty arthritis attacks ⓘ treatment of gout ⓘ treatment of hyperuricemia ⓘ |
| increasesRenalExcretionOf | uric acid ⓘ |
| increasesSerumConcentrationOf | penicillin ⓘ |
| isAdministeredAs | oral tablet ⓘ |
| isContraindicatedIn |
acute gout attack
ⓘ
severe renal impairment ⓘ uric acid kidney stones ⓘ |
| isExcretedBy | kidney ⓘ |
| isIndicatedFor |
chronic gout
ⓘ
hyperuricemia associated with gout ⓘ |
| isListedOn | World Health Organization Model List of Essential Medicines NERFINISHED ⓘ |
| isMetabolizedBy | liver ⓘ |
| isProteinBound | high protein binding ⓘ |
| mayCauseAdverseEffect |
gastrointestinal upset
ⓘ
headache ⓘ kidney stones ⓘ rash ⓘ |
| modifiesPharmacokineticsOf |
cephalosporins
ⓘ
penicillin NERFINISHED ⓘ some antiviral drugs ⓘ |
| wasFirstApprovedIn | 1951 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.