diphtheria
E824428
Diphtheria is a serious, potentially life-threatening infectious disease caused by Corynebacterium diphtheriae, characterized by sore throat, fever, and a thick gray membrane in the throat that can obstruct breathing.
Statements (57)
| Predicate | Object |
|---|---|
| instanceOf |
infectious disease
ⓘ
toxin-mediated disease ⓘ |
| affectedSystem |
cardiovascular system
ⓘ
nervous system ⓘ respiratory system ⓘ |
| causativeAgent | Corynebacterium diphtheriae NERFINISHED ⓘ |
| hasCause | infection with toxigenic strains of Corynebacterium diphtheriae ⓘ |
| hasComplication |
cardiac arrhythmia
ⓘ
death ⓘ heart failure ⓘ paralysis ⓘ respiratory failure ⓘ |
| hasForm |
cutaneous diphtheria
ⓘ
laryngeal diphtheria ⓘ respiratory diphtheria ⓘ |
| hasPathologicalFeature |
local tissue necrosis
ⓘ
pseudomembrane formation on tonsils and pharynx ⓘ systemic absorption of diphtheria toxin ⓘ |
| hasToxin | diphtheria toxin ⓘ |
| historicalSignificance | major cause of childhood mortality before widespread vaccination ⓘ |
| ICD10 | A36 ⓘ |
| incubationPeriod | typically 2 to 5 days ⓘ |
| isNotifiableDiseaseIn | many countries worldwide ⓘ |
| modeOfAction | inhibition of host cell protein synthesis by diphtheria toxin ⓘ |
| prevention |
DTaP vaccine
ⓘ
Td vaccine booster ⓘ Tdap vaccine ⓘ diphtheria toxoid vaccine ⓘ good respiratory hygiene ⓘ |
| riskFactor |
crowded living conditions
ⓘ
incomplete vaccination ⓘ lack of vaccination ⓘ poor hygiene ⓘ travel to endemic areas ⓘ |
| symptom |
airway obstruction
ⓘ
bull neck swelling ⓘ difficulty swallowing ⓘ fever ⓘ hoarseness ⓘ malaise ⓘ myocarditis ⓘ peripheral neuropathy ⓘ sore throat ⓘ swollen neck lymph nodes ⓘ thick gray pseudomembrane in throat ⓘ |
| transmission |
close person-to-person contact
ⓘ
contact with contaminated objects ⓘ respiratory droplets ⓘ |
| treatment |
airway management
ⓘ
antibiotics ⓘ diphtheria antitoxin ⓘ erythromycin ⓘ penicillin ⓘ supportive care ⓘ |
| vaccineSchedule | childhood primary series with periodic boosters ⓘ |
| vaccineType | inactivated toxoid ⓘ |
| zoonoticStatus | primarily human disease ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.