irinotecan
E823218
Irinotecan is a chemotherapy drug, specifically a topoisomerase I inhibitor, commonly used to treat colorectal and other cancers.
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
camptothecin derivative
ⓘ
chemotherapy drug ⓘ prodrug ⓘ topoisomerase I inhibitor ⓘ |
| hasActiveMetabolite | SN-38 NERFINISHED ⓘ |
| hasApprovalYear | 1996 ⓘ |
| hasATCCode | L01CE02 ⓘ |
| hasBlackBoxWarningFor |
myelosuppression
ⓘ
severe diarrhea ⓘ |
| hasCASNumber | 97682-44-5 ⓘ |
| hasCommonSideEffect |
abdominal pain
ⓘ
alopecia ⓘ diarrhea ⓘ nausea ⓘ neutropenia ⓘ vomiting ⓘ |
| hasEliminationRoute |
biliary excretion
ⓘ
fecal excretion ⓘ renal excretion ⓘ |
| hasIndication |
advanced colorectal cancer
ⓘ
cervical cancer ⓘ gastric cancer ⓘ metastatic colorectal cancer ⓘ ovarian cancer ⓘ pancreatic cancer ⓘ small cell lung cancer ⓘ |
| hasIUPACName | (4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidinopiperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ⓘ |
| hasMechanismOfAction | inhibition of DNA topoisomerase I ⓘ |
| hasMolecularFormula | C33H38N4O6 ⓘ |
| hasOrigin | semisynthetic derivative of camptothecin ⓘ |
| hasPharmacologicClass |
antineoplastic agent
ⓘ
topoisomerase inhibitor ⓘ |
| hasPregnancyCategory | D (US, historical classification) ⓘ |
| hasRouteOfAdministration | intravenous ⓘ |
| hasSeriousSideEffect |
severe diarrhea
ⓘ
severe neutropenia ⓘ |
| isAdministeredBy | intravenous infusion ⓘ |
| isComponentOfRegimen |
FOLFIRI
NERFINISHED
ⓘ
XELIRI NERFINISHED ⓘ |
| isContraindicatedIn |
known hypersensitivity to irinotecan
ⓘ
severe bone marrow suppression ⓘ |
| isInactivatedBy | UGT1A1 NERFINISHED ⓘ |
| isMetabolizedBy |
CYP3A4
NERFINISHED
ⓘ
CYP3A5 NERFINISHED ⓘ carboxylesterase enzymes ⓘ |
| isProdrugOf | SN-38 NERFINISHED ⓘ |
| isSubstrateOf | P-glycoprotein ⓘ |
| isTeratogenic | yes ⓘ |
| targets | DNA topoisomerase I ⓘ |
| wasApprovedBy | U.S. Food and Drug Administration NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.