carbidopa
E804842
Carbidopa is a medication used in combination with levodopa to treat Parkinson’s disease by preventing peripheral breakdown of levodopa and reducing its side effects.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
antiparkinsonian agent
ⓘ
decarboxylase inhibitor ⓘ pharmaceutical drug ⓘ small molecule ⓘ |
| actsOn | aromatic L-amino acid decarboxylase ⓘ |
| belongsToClass | hydrazine derivatives ⓘ |
| bioavailability | about 40–70% ⓘ |
| commonAdverseEffect |
dizziness
ⓘ
dry mouth ⓘ dyskinesia (when combined with levodopa) ⓘ nausea ⓘ orthostatic hypotension ⓘ |
| contraindicatedWith | nonselective MAO inhibitors ⓘ |
| developedFor | enhancing levodopa therapy ⓘ |
| doesNotCross | blood–brain barrier effectively ⓘ |
| eliminationHalfLife | about 1.5–2 hours ⓘ |
| firstApprovalDecade | 1970s GENERATED ⓘ |
| firstApprovedIn | United States NERFINISHED ⓘ |
| hasATCCode | N04BA02 ⓘ |
| hasCASNumber | 28860-95-9 ⓘ |
| hasChemicalFormula | C10H14N2O4 ⓘ |
| hasDrugBankID | DB00190 ⓘ |
| hasIUPACName | (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid ⓘ |
| hasMolarMass | 226.23 g/mol ⓘ |
| hasPubChemCID | 34359 ⓘ |
| hasStereochemistry | L-enantiomer is active form ⓘ |
| increases | central nervous system availability of levodopa ⓘ |
| isComponentOf |
Parcopa
NERFINISHED
ⓘ
Rytary NERFINISHED ⓘ Sinemet NERFINISHED ⓘ carbidopa/levodopa combination product ⓘ |
| isListedOn | World Health Organization Model List of Essential Medicines NERFINISHED ⓘ |
| legalStatusEU | prescription only ⓘ |
| legalStatusUS | prescription only ⓘ |
| mayCause |
confusion (with levodopa)
ⓘ
hallucinations (with levodopa) ⓘ |
| mechanismOfAction | inhibits peripheral aromatic L-amino acid decarboxylase ⓘ |
| pregnancyCategoryUS | C ⓘ |
| primaryEliminationRoute | renal GENERATED ⓘ |
| proteinBinding | about 36% ⓘ |
| reduces |
levodopa-induced cardiovascular side effects
ⓘ
levodopa-induced nausea ⓘ levodopa-induced vomiting ⓘ peripheral metabolism of levodopa ⓘ |
| routeOfAdministration | oral ⓘ |
| treats |
Parkinson's disease
NERFINISHED
ⓘ
Parkinsonian syndrome NERFINISHED ⓘ |
| usedInCombinationWith | levodopa ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.