The Double Helix (scientific contribution, not the book author)
E78353
The Double Helix is the iconic structural model of DNA, revealing its two-stranded, twisted-ladder configuration that underpins modern molecular biology and genetics.
Aliases (4)
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
DNA structural model
→
molecular biology concept → scientific model → |
| describes |
two-stranded structure of DNA
→
|
| enables |
development of DNA sequencing methods
→
development of genetic engineering → development of molecular cloning techniques → understanding of mutation at the molecular level → understanding of recombination at the molecular level → |
| hasBackboneBondType |
phosphodiester bonds
→
|
| hasBondType |
hydrogen bonds between complementary bases
→
|
| hasComponent |
two antiparallel polynucleotide strands
→
|
| hasConsequence |
explains Chargaff’s rules via base pairing
→
suggests semi-conservative replication mechanism → |
| hasDiameter |
about 2 nanometers in B-DNA
→
|
| hasFeature |
base pairs perpendicular to helix axis
→
complementary base pairing → nitrogenous bases on the inside → sugar-phosphate backbone on the outside → |
| hasFunction |
explains mechanism of DNA replication
→
explains mechanism of genetic information storage → provides basis for understanding genetic inheritance → provides framework for molecular genetics → |
| hasHistoricalImpact |
founded modern molecular biology
→
revolutionized genetics → |
| hasPitch |
about 10 base pairs per turn in B-DNA
→
|
| hasProperty |
antiparallel strand orientation (5′ to 3′ and 3′ to 5′)
→
|
| hasShape |
right-handed helix
→
|
| hasStructuralFeature |
major groove
→
minor groove → |
| involvesBasePair |
adenine–thymine base pair
→
guanine–cytosine base pair → |
| isAssociatedWith |
Watson–Crick model of DNA
→
central dogma of molecular biology → |
| isBasedOn |
X-ray diffraction data of DNA fibers
→
|
| isCanonicalFormOf |
B-form DNA
→
|
| isIconicIn |
biochemistry
→
biological sciences → |
| isTaughtIn |
genetics education
→
molecular biology education → |
| represents |
three-dimensional structure of DNA
→
|
| symbolizes |
genetic information
→
modern molecular biology → |
| underpins |
biotechnology
→
genomics → structural biology of nucleic acids → |
Referenced by (5)
| Subject (surface form when different) | Predicate |
|---|---|
|
Francis Crick
→
James Watson ("The Double Helix: A Personal Account of the Discovery of the Structure of DNA") → |
notableWork |
|
Time magazine Top 100 non-fiction books since 1923
("The Double Helix")
→
|
hasPart |
|
The Double Helix
("Watson–Crick model of DNA")
→
|
isAssociatedWith |
|
James Watson
("The Double Helix (book)")
→
|
knownFor |