Humira
E697096
Humira is a widely used biologic medication (adalimumab) that treats various autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn’s disease by inhibiting tumor necrosis factor (TNF).
All labels observed (1)
| Label | Occurrences |
|---|---|
| Humira canonical | 1 |
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
biologic medication
ⓘ
monoclonal antibody ⓘ tumor necrosis factor inhibitor ⓘ |
| approvalBy |
European Medicines Agency
NERFINISHED
ⓘ
U.S. Food and Drug Administration NERFINISHED ⓘ |
| approvalYear | 2002 ⓘ |
| bindsTo |
membrane-bound TNF-alpha
ⓘ
soluble TNF-alpha ⓘ |
| blackBoxWarning |
malignancy
ⓘ
serious infections ⓘ |
| commonAdverseEffect |
headache
ⓘ
injection site reaction ⓘ upper respiratory tract infection ⓘ |
| contraindication |
active serious infection
ⓘ
moderate to severe heart failure ⓘ |
| developer | AbbVie NERFINISHED ⓘ |
| hasATCCode | L04AB04 ⓘ |
| hasDosageForm |
pre-filled pen
ⓘ
pre-filled syringe ⓘ |
| hasDrugClass |
TNF-alpha inhibitor
ⓘ
immunosuppressive agent ⓘ |
| hasGenericName | adalimumab ⓘ |
| hasINN | adalimumab ⓘ |
| hasRouteOfAdministration | subcutaneous injection ⓘ |
| indication |
Crohn's disease
ⓘ
ankylosing spondylitis ⓘ hidradenitis suppurativa ⓘ juvenile idiopathic arthritis ⓘ non-infectious intermediate uveitis ⓘ non-infectious panuveitis ⓘ non-infectious posterior uveitis ⓘ plaque psoriasis ⓘ psoriatic arthritis ⓘ rheumatoid arthritis ⓘ ulcerative colitis ⓘ uveitis ⓘ |
| isAdministeredBy | patient self-injection ⓘ |
| isBiologic | true ⓘ |
| isBiosimilarAvailable | true ⓘ |
| mechanismOfAction | binds to TNF-alpha and blocks its interaction with TNF receptors ⓘ |
| molecularType | recombinant human IgG1 monoclonal antibody ⓘ |
| originalDeveloper | Abbott Laboratories NERFINISHED ⓘ |
| pregnancyCategoryUS | B ⓘ |
| reduces | inflammatory response mediated by TNF-alpha ⓘ |
| requiresMonitoring |
hepatitis B reactivation
ⓘ
signs of infection ⓘ tuberculosis ⓘ |
| targets | tumor necrosis factor alpha NERFINISHED ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.