nearly neutral theory of molecular evolution
E612270
The nearly neutral theory of molecular evolution is an extension of neutral theory that posits most evolutionary changes at the molecular level are due to mutations with very slight deleterious or advantageous effects whose fate is strongly influenced by genetic drift and population size.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
evolutionary theory
ⓘ
molecular evolution theory ⓘ population genetics theory ⓘ |
| accountsFor |
high levels of molecular polymorphism
ⓘ
lineage-specific differences in dN/dS ratios ⓘ |
| addresses | distribution of fitness effects of new mutations ⓘ |
| assumes |
boundary between neutral and selected mutations depends on population size
ⓘ
many mutations have very small selection coefficients ⓘ |
| basedOn | neutral theory of molecular evolution ⓘ |
| category |
theories of genetic drift
ⓘ
theories of molecular evolution ⓘ theories of natural selection ⓘ |
| contrastsWith | strict neutral theory of molecular evolution ⓘ |
| dependsOn | effective population size ⓘ |
| developedIn | 1970s ⓘ |
| emphasizes |
importance of nearly neutral mutations
ⓘ
interaction between selection and genetic drift ⓘ role of effective population size ⓘ |
| explains |
molecular clock patterns
ⓘ
variation in substitution rates among lineages ⓘ |
| extends | neutral theory of molecular evolution NERFINISHED ⓘ |
| field |
evolutionary biology
ⓘ
molecular evolution ⓘ population genetics ⓘ |
| focusesOn | molecular level evolutionary changes ⓘ |
| hasImplication |
evolution of genome size
ⓘ
evolutionary rates in endosymbionts and island species ⓘ genome-wide patterns of constraint ⓘ |
| influencedBy | Motoo Kimura NERFINISHED ⓘ |
| involvesConcept |
effective population size
ⓘ
fixation probability ⓘ genetic drift ⓘ natural selection ⓘ selection coefficient ⓘ slightly advantageous mutations ⓘ slightly deleterious mutations ⓘ |
| predicts |
greater fixation of slightly deleterious mutations in small populations
ⓘ
more efficient purifying selection in large populations ⓘ rate of molecular evolution can depend on population size ⓘ |
| proposedBy | Tomoko Ohta NERFINISHED ⓘ |
| reconciles | molecular data with weak selection ⓘ |
| relatedTo | Kimura's neutral theory of molecular evolution NERFINISHED ⓘ |
| statesThat |
most molecular mutations are slightly deleterious or slightly advantageous
ⓘ
the fate of slightly advantageous mutations is strongly influenced by genetic drift ⓘ the fate of slightly deleterious mutations is strongly influenced by genetic drift ⓘ |
| usedIn |
interpretation of divergence data
ⓘ
interpretation of polymorphism data ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.