Kimura two-parameter model

E612268

The Kimura two-parameter model is a foundational mathematical model in molecular evolution that describes DNA sequence change by distinguishing between transition and transversion substitution rates.

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Statements (47)

Predicate Object
instanceOf Markov model of sequence evolution
mathematical model in molecular evolution
nucleotide substitution model
substitution model
alsoKnownAs K2P model
K80 model NERFINISHED
appliesTo DNA sequences
assumes constant substitution rates across sites
equal base frequencies
homogeneous substitution process over time
independent evolution at different sites
time-reversible substitution process
basedOn continuous-time Markov chain
belongsTo field of molecular evolution
field of population genetics
comparedWith HKY85 model NERFINISHED
Jukes–Cantor model NERFINISHED
Tamura–Nei model NERFINISHED
defines expected proportion of nucleotide differences
distinguishes transition substitution rate
transversion substitution rate
domain nucleotide positions in DNA
generalizes Jukes–Cantor model NERFINISHED
hasAssumption no insertion–deletion events
stationary nucleotide composition
hasParameter overall evolutionary distance
transition rate parameter
transversion rate parameter
implementedIn BEAST NERFINISHED
MEGA software NERFINISHED
MrBayes NERFINISHED
PAUP* NERFINISHED
PHYLIP NERFINISHED
RAxML NERFINISHED
influenced development of more complex nucleotide substitution models
isSpecialCaseOf general time reversible model
mathematicallyCharacterizedBy two distinct substitution rate parameters
namedAfter Motoo Kimura NERFINISHED
proposedBy Motoo Kimura NERFINISHED
publicationYear 1980
usedFor correcting multiple substitutions at the same site
estimating evolutionary divergence between sequences
usedIn DNA sequence alignment analysis
distance-based phylogenetic methods
maximum likelihood phylogenetic inference
molecular evolutionary distance estimation
phylogenetic tree reconstruction

Referenced by (1)

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Motoo Kimura knownFor Kimura two-parameter model