Vivitrol
E597292
Vivitrol is an extended-release injectable formulation of naltrexone used to treat alcohol and opioid dependence by blocking the effects of these substances.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
extended-release injectable formulation ⓘ medication ⓘ |
| activeIngredient | naltrexone ⓘ |
| administrationBy | healthcare professional ⓘ |
| ATCCode | N07BB04 NERFINISHED ⓘ |
| blackBoxWarning |
risk of hepatotoxicity with naltrexone
ⓘ
vulnerability to opioid overdose after treatment ⓘ |
| commonAdverseEffect |
dizziness
ⓘ
elevated liver enzymes ⓘ fatigue ⓘ headache ⓘ injection site pain ⓘ nausea ⓘ |
| contraindication |
acute hepatitis
ⓘ
acute opioid withdrawal ⓘ current opioid use ⓘ failure to pass naloxone challenge test ⓘ liver failure ⓘ positive opioid urine screen ⓘ |
| dosageForm | suspension for injection ⓘ |
| dosingInterval | once monthly ⓘ |
| effect |
blocks effects of exogenous opioids
ⓘ
reduces rewarding effects of alcohol ⓘ |
| eliminationHalfLife | approximately 5–10 days (extended-release) ⓘ |
| FDAApprovalYear | 2006 ⓘ |
| FDAApprovedFor |
prevention of relapse to opioid dependence after opioid detoxification
ⓘ
treatment of alcohol dependence ⓘ |
| formulationType | extended-release ⓘ |
| indication |
alcohol dependence
ⓘ
opioid dependence ⓘ prevention of relapse to opioid dependence ⓘ |
| legalStatus | prescription only ⓘ |
| manufacturer | Alkermes plc NERFINISHED ⓘ |
| mechanismOfAction |
blocks mu-opioid receptors
ⓘ
opioid receptor antagonist ⓘ |
| pregnancyCategoryUS | Category C ⓘ |
| requires | opioid-free period of at least 7–10 days before initiation ⓘ |
| routeDetail | deep intramuscular injection in the gluteal muscle ⓘ |
| routeOfAdministration | intramuscular injection ⓘ |
| seriousAdverseEffect |
depression
ⓘ
hepatitis ⓘ injection site necrosis ⓘ suicidal ideation ⓘ |
| strength | 380 mg naltrexone base ⓘ |
| usedWith |
counseling
ⓘ
psychosocial support ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.